DIPPER: a spatiotemporal proteomics atlas of human intervertebral discs for exploring ageing and degeneration dynamics
Vivian Tam1,2*, Peikai Chen1*, Anita Yee1, Nestor Solis3, Theo Klein3,4, Mateusz Kudelko1, Rakesh Sharma5, Wilson Chan1,2,6 Christopher Overall3, Lisbet Haglund7, Pak C Sham8, Kathryn S E Cheah1, Danny Chan1,2
* These authors contributed equally to this manuscript
https://elifesciences.org/articles/64940

in-house data (PMID: 33382035): High resolution human LC-MS/MS static spatial proteome of young and aged AF/NPs (n=66)
Human transcriptomic data of YND and AGD AF/NP (n=8)
Human MRI images

public data: Anne Camus's human in vitro NLC RNAseq (PMID: 32102328)
Yuelin Zhang's NCC/NPC culture from human ESC (PMID: 32101752)
Cheryle's mouse array AF/NPs multi-TPs (PMID: 31597481)
Steve Richardson/Judith Hoyland: CD24+/- microarray (PMID: 28473691)
Judith NPC/AC microarray (PMID: 20722018)


Pre-print: https://www.biorxiv.org/content/10.1101/2020.07.11.192948v3
The codes/scripts are available at https://github.com/hkudclab/DIPPER
1 School of Biomedical Sciences, The University of Hong Kong, Hong Kong;
2 The University of Hong Kong Shenzhen of Research Institute and Innovation (HKU-SIRI), Shenzhen, China;
3 Centre for Blood Research, University of British Columbia, Vancouver, Canada;
4 Present address: Triskelion BV, Zeist, The Netherlands;
5 Proteomics and Metabolomics Core Facility, The University of Hong Kong, Hong Kong;
6 Department of Orthopaedics Surgery and Traumatology, HKU-Shenzhen Hospital, Shenzhen, China;
7 Department of Surgery, McGill University, Montreal, Canada;
8 Centre for PanorOmic Sciences (CPOS), The University of Hong Kong, Hong Kong.

KSEC is a senior editor at eLife. All other authors declare that they do not have any conflict of interests

Correspondence should be addressed to:
Danny Chan
School of Biomedical Sciences
Faculty of Medicine
The University of Hong Kong
21 Sassoon Road, Hong Kong
Email: chand@hku.hk
Tel.: +852 3917 9482









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