DIPPER: a spatiotemporal proteomics atlas of human intervertebral discs for exploring ageing and degeneration dynamics

Vivian Tam^1,2*, Peikai Chen^1*, Anita Yee¹, Nestor Solis³, Theo Klein^3,4, Mateusz Kudelko¹, Rakesh Sharma⁵, Wilson Chan^1,2,6 Christopher Overall³, Lisbet Haglund⁷, Pak C Sham⁸, Kathryn S E Cheah¹, Danny Chan^1,2

* These authors contributed equally to this manuscript

https://elifesciences.org/articles/64940

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in-house data (PMID: 33382035): High resolution human LC-MS/MS static spatial proteome of young and aged AF/NPs (n=66)
Human transcriptomic data of YND and AGD AF/NP (n=8)
Human MRI images

public data: Anne Camus's human in vitro NLC RNAseq (PMID: 32102328)

Yuelin Zhang's NCC/NPC culture from human ESC (PMID: 32101752)

Cheryle's mouse array AF/NPs multi-TPs (PMID: 31597481)

Steve Richardson/Judith Hoyland: CD24+/- microarray (PMID: 28473691)

Judith NPC/AC microarray (PMID: 20722018)

Pre-print: https://www.biorxiv.org/content/10.1101/2020.07.11.192948v3
The codes/scripts are available at https://github.com/hkudclab/DIPPER
¹ School of Biomedical Sciences, The University of Hong Kong, Hong Kong;
² The University of Hong Kong Shenzhen of Research Institute and Innovation (HKU-SIRI), Shenzhen, China;
³ Centre for Blood Research, University of British Columbia, Vancouver, Canada;
⁴ Present address: Triskelion BV, Zeist, The Netherlands;
⁵ Proteomics and Metabolomics Core Facility, The University of Hong Kong, Hong Kong;
⁶ Department of Orthopaedics Surgery and Traumatology, HKU-Shenzhen Hospital, Shenzhen, China;
⁷ Department of Surgery, McGill University, Montreal, Canada;
⁸ Centre for PanorOmic Sciences (CPOS), The University of Hong Kong, Hong Kong.

KSEC is a senior editor at eLife. All other authors declare that they do not have any conflict of interests

Correspondence should be addressed to:
Danny Chan
School of Biomedical Sciences
Faculty of Medicine
The University of Hong Kong
21 Sassoon Road, Hong Kong
Email: chand@hku.hk
Tel.: +852 3917 9482