Professor D. Grahame Hardie
Professor of Cellular Signalling
Division of Cell Signalling & Immunology
College of Life Sciences
University of Dundee, Scotland, UK

Date: Wednesday, 28-March-2018
Time: 4:00 p.m.
Venue: Room A2-08, Mrs Chen Yang Foo Oi Telemedicine Centre 
2/F, William MW Mong Block, Faculty of Medicine Building 
21 Sassoon Road, Pokfulam, Hong Kong

Summary:

AMPK is best known for sensing cellular energy status by monitoring AMP:ATP and ADP:ATP ratios, and restoring energy homeostasis by switching on ATP-producing, catabolic processes and switching off ATP-consuming processes. However, in collaboration with Shengcai Lin at the University of Xiamen, we have recently shown that AMPK is able to sense glucose via an AMP/ADP-independent mechanism involving formation of a 'super-complex' of AMPK, LKB1, Axin, p18/Lamtor1 and v-ATPase at the surface of the lysosome. Professor Hardie will present the evidence supporting this mechanism, and speculate as to why glucose-sensing might take place at the lysosome.

ALL ARE WELCOME