Nov 13, 2019
Seminar - Cooperativity of RNA-binding proteins in gene regulation and disease (Speaker: Professor Dr. Dierk Niessing)
Professor Dr. Dierk Niessing
Institute of Pharmaceutical Biotechnology, Ulm University, Germany
Date: Wednesday, 13-November-2019
Time: 4:00 p.m.
Venue: Seminar Room 2, G/F, Laboratory Block, Faculty of Medicine Building
21 Sassoon Road, Pokfulam, Hong Kong
Gene regulation at the level of mRNAs has been proven equally important as transcriptional regulation. Advantages of translational over transcriptional control are the faster response to regulatory signals and the ability to regulate protein expression in defined subcellular regions of a cell. The latter is for instance important for neuronal activity and (stem-) cell division. In this talk, molecular and structural principles of specific RNA binding for translational control will be discussed. Examples from speaker’s lab will be given where for specific RNA recognition multiple domains have to cooperate. In one of these examples, failure of cooperative interaction of domains results in the neurodevelopmental disorder PURA syndrome.
ALL ARE WELCOME