Professor Ketan Patel
MRC Laboratory of Molecular Biology
Cambridge Biomedical Campus, Cambridge, UK

Date: Friday, 18-January-2019
Time: 4:00 p.m.
Venue: Seminar Room 5, LG1/F, Laboratory Block, Faculty of Medicine Building
21 Sassoon Road, Pokfulam, Hong Kong

Summary:
Professor Patel’s team have identified that endogenous and alcohol derived aldehydes are a major source of endogenous DNA damage. A two-tier protection mechanism ensures that endogenous aldehydes do not cause permanent DNA damage and mutagenesis. New findings also reveal how a DNA crosslink caused by acetaldehyde is repaired, and they suggest the existence of a new DNA crosslink repair pathway that does not require DNA excision.

ALL ARE WELCOME