Dr. Sumana Sanyal
School of Public Health & School of Biomedical Sciences
The University of Hong Kong

Date: Wednesday, 6-March-2019
Time: 9:00 a.m.
Venue: Seminar Room L3-38, 3/F, Laboratory Block, Faculty of Medicine Building
21 Sassoon Road, Pokfulam, Hong Kong

Summary:
Ubiquitylation is one of the most versatile and abundant post translational modifications with critical roles in protein turnover and regulation of signaling pathways. It is routinely targeted during virus infections to dysregulate cellular homeostasis. Dr Sanyal’s group identified several deubiquitylases that are specifically induced upon influenza virus infection. Here, Dr Sanyal will discuss the function of one such deubiquitylase - OTUB1 - which is interferon inducible and a positive regulator of the RIG-I signaling pathway. OTUB1 stabilises the RIG-I signaling complex to activate downstream transcription factors, and is targeted for proteasomal degradation by influenza NS1.

ALL ARE WELCOME