Principal Investigators

Chen, Jeng-Haur
The structure and function of a Cl^– channel, the cystic fibrosis transmembrane conductance regulator (CFTR) The respiratory infectious diseases

Cheung, Lydia Wai Ting
Functional genomics for translational cancer medicine Cancer biology

Cheung, Martin Chi Hang
Genetic control of neural crest formation, delamination and migration Live cell imaging of neural crest migratory behavior Molecular mechanisms of cancer metastasis

Gao, Bo
Cell signaling in development and disease

Lai, Cora Sau Wan
Synaptic plasticity in learning and memory

Lai, Kwok On
Novel signaling mechanisms that regulate dendritic spine morphogenesis in response to neuronal activity RNA trafficking and local protein synthesis in neuronal dendrites

Lee, Chi Wai
Intracellular trafficking of proteins and organelles Cytoskeletal dynamics in neuronal motility Pathogenesis of muscular dystrophy

Lim, Lee Wei
Deep brain stimulation in neurological and neuropsychiatric diseases Behavioral, cellular and molecular neurosciences

Ma, Stephanie Kwai Yee
Exploiting stemness as a cancer cell vulnerability

Study on the epigenetic control in haematopoiesis using embryonic stem cells
Improvement of ex vivo expansion of haematopoietic stem cell population by epigenetic manipulations
Identification of leukaemogenic genes in MLL-rearranged leukaemia
Investigation of the correlation between DNA methylation/histone modifications and gene expression in haematopoietic/leukaemia stem cells
Global study of DNA methylation patterns in the development of leukaemia stem cells
Epigenetic studies of haematopoietic and leukaemia stem cells

Qian, Chengmin
Structural biology and epigenetics Structural Biology Epigenetics DNA Damage Response

Wong, Alan Siu Lun (joint appointment with Department of Electrical and Electronic Engineering)
Combinatorial genetics Synthetic biology Genome engineering Disease biology

Yu, Cheng-Han
Integrin signaling in cell-matrix adhesion Lipid signaling in podosomes and invadopodia Mechanobiology and cancer metastasis Advanced fluorescence microscopy and image analysis Bio-functionalized supported lipid membrane

Chan, Vera Sau Fong (joint appointment with Department of Medicine)
Innate receptors immunobiology: C-type lectin receptors and Toll-like receptors and their roles in autoimmune diseases and infection Cellular immuno-dysregulation in systemic lupus erythematosus Molecular profiling and biomarkers development for SLE Molecular and cellular immunology; animal models for autoimmune diseases

Lian, Qizhou (joint appointment with Department of Medicine)
Human pluripotent stem cells and lineage differentiation Mesenchymal stem cells Stem cells and gene therapies for cardiovascular, muscular and neural metabolic diseases

Sanyal, Sumana (joint appointment with School of Public Health)
Host pathogen interactions Post-translational protein regulation by ubiquitylation Lipid metabolism Innate immune signaling in virus infections

TANG, Eva Hoi-Ching (joint appointment with Department of Pharmacology and Pharmacy)

The role of the telomeric protein, repressor activator protein 1 (Rap1) in vascular function and lipid metabolism.
The role of prostaglandins and their receptors in adipose tissue inflammation.
Anti-inflammatory role of prostaglandin E receptor (EP4) in atherosclerosis, abdominal aortic aneurysm and obesity.
Endothelial dysfunction in the vascular system, endothelium-dependent contractions in hypertension, TP receptor antagonists in treatment of endothelial dysfunction.

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