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Academic Staff

Dr WONG, Alan Siu Lun 黃兆麟 (joint appointment with Department of Electrical and Electronic Engineering)

Dr WONG, Alan Siu Lun 黃兆麟 (joint appointment with Department of Electrical and Electronic Engineering)

  • BSc, MPhil (CUHK); PhD (HKUST)
  • Assistant Professor
L3-76, Laboratory Block, 21 Sassoon Road, Hong Kong
+852 3917 9208
+852 2855 1254
  • Combinatorial genetics
  • Genome engineering
  • Protein engineering
  • Synthetic biology
  • Disease biology
  • Combination therapy
  • Postdoctoral Fellow/Associate, MIT Synthetic Biology Center, Research Laboratory of Electronics, Massachusetts Institute of Technology, USA (2012-2016)
  • Ph.D., The Hong Kong University of Science and Technology, Hong Kong (2007-2011)
  • M.Phil., The Chinese University of Hong Kong, Hong Kong (2005-2007)
  • B.Sc., The Chinese University of Hong Kong, Hong Kong (2002-2005)

Many human diseases are caused by multigenic perturbations. Our research takes an integrative approach leveraging on various techniques in synthetic biology, CRISPR-based genome engineering, high-throughput sequencing, molecular biology, and genetics to decode the complex genetic bases of human diseases including cancers and neurodegenerative disorders. Our laboratory aims to develop and apply new technologies to interrogate and understand the complex biological systems, and rationally design and engineer genetic circuits for providing new biomedical and biotechnological solutions.

combiGEM  combiGEM-CRISPR

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Research topics will focus on developing and applying cutting-edge technologies (e.g. CombiGEM, CombiGEM-CRISPR, and CombiSEAL) for studying complex disease biology, devising new therapeutic strategies, and engineering new proteins. Interested candidates are encouraged to contact Dr. Wong and our lab webpage ( for more details.

  1. Choi, C.G.G., Zhou, P., Yuen, T.L.C., Chan, K.C.B., Xu, F., Bao, S., Chu, H.Y., Thean, D., Tan, K., Wong, K.H., Zheng, Z., Wong, S.L.A.# Combinatorial mutagenesis en masse optimizes SpCas9’s genome-editing activities. Nature Methods 16(8), 722-730 (2019) (#Corresponding author)
    Featured in Springer Nature Protocols and Methods Community:
  2. Leung, C.S., Li ,J., Xu, F., Wong, S.L.A., Lui, K.O. Ectopic expression of recipient CD47 inhibits mouse macrophage-mediated immune rejection against human stem cell transplants. FASEB J. 33(1): 484-493 (2019).
  3. Wong, S.L.A., Choi, C.G.G., Lu, T.K. Deciphering combinatorial genetics. Annual Review of Genetics 50, 515-538 (2016). []
  4. Wong, S.L.A.*, Choi, C.G.G.*, Cui, C.H.*, Pregernig, G., Milani, P., Adam, M., Perli, S.D., Kazer, S.W., Gaillard, A., Hermann, M., Shalek, A.K., Fraenkel, E., Lu, T.K. Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM. Proceedings of National Academy of Sciences 113(9), 2544-2549 (2016). (*Equal contributions).
  5. Wong, S.L.A., Choi, C.G.G., Cheng, A.A., Purcell, O., Lu, T.K. Massively parallel high-order combinatorial genetics in human cells. Nature Biotechnology 33(9), 952-961 (2015).
  6. Lai, K.O., Wong, S.L.A., Cheung, M.C., Xu, P., Liang, Z., Lok, K.C., Xie, H., Palkos, M.E., Yung, W.H., Tessarollo, L., Cheung, Z.H., Ip, N.Y. TrkB phosphorylation by Cdk5 is required for activity-dependent structural plasticity and spatial memory. Nature Neuroscience 15(11), 1506-1515 (2012).
  7. Wong, S.L.A., Lee, R.H.K., Cheung, A.Y., Yeung, P.K., Chung, S.K., Cheung, Z.H. and Ip, N.Y. Cdk5-mediated phosphorylation of endophilin B1 is required for induced autophagy in models of Parkinson’s disease. Nature Cell Biology 13(5), 568-579 (2011).
  8. Wong, S.L.A., Cheung, Z.H. and Ip, N.Y. Molecular machinery of macroautophagy and its deregulation in diseases. Biochimica et Biophysica Acta – Molecular Basis of Disease 1812(11), 1490-1479 (2011).
  9. Wong, S.L.A., Chan, W. M. and Chan, H.Y.E. Sodium dodecyl sulfate-insoluble oligomers are involved in polyglutamine degeneration. FASEB J. 22(9), 3348-3357 (2008).
  10. Huen, N.Y.M., Wong, S.L.A. and Chan, H.Y.E. Transcriptional malfunctioning of heat shock protein gene expression in spinocerebeller ataxias. The Cerebellum 6(2), 111-117 (2006).
  11. Wong, S.L.A., Chen, Y.W., Chan, C.M., Chan, C.S.M., Chan, P.K.S., Chui, Y.L., Fung, K.P., Waye, M.M.Y., Tsui, S.K.W. and Chan, H.Y.E. In vivo functional characterization of the SARS Coronavirus 3a protein in DrosophilaBiochem. Biophy. Res. Comm. 337, 720-729 (2005).
    • Featured on Cover of the issue.
  • RGC – General Research Fund (GRF) 2020/21 (PI)
  • RGC – General Research Fund (GRF) 2019/20 (PI)
  • CRF – Collaborative Research Fund (CRF) 2019/2020 (Co-PI)
  • Karolinska Institutet – MWLC Associate Membership Fund 2019, Karolinska Institutet, HK (PI)
  • CRF – Collaborative Research Fund (CRF) 2018/2019 (Co-PI)
  • ITF – Innovation and Technology Fund (ITF) Tier 3 2018/2019 (PI)
  • RGC – General Research Fund (GRF) 2018/2019 (PI)
  • RGC – General Research Fund (GRF) 2018/2019 (Co-I)
  • RGC – Theme-based Research Scheme 2016/2017 (Co-I)
  • RGC – Early Career Scheme (ECS) 2016/2017 (PI)
  • Health and Medical Research Fund (HMRF) 2015 (PI)
  • Croucher Startup Allowance (PI)
  • Early Career Award, Research Grant Council, Hong Kong (2016/2017)
  • Croucher Fellowship (2012-2014)
  • Young Scientist Award in Life Science, Hong Kong Institution of Science (2011)
  • Postgraduate Achievement Award, Division of Life Science, HKUST (2010)
  • Best Teaching Assistant Award in Biochemistry of Nucleic Acid, HKUST (2009/2010)
  • Croucher Research Studentship (2008-2010)
  • Butterfield-Croucher Studentship (2008/2009)
  • Sir Edward Youde Memorial Fellowship (2008/2009)
  • Essex Bio-Technology Limited Scholarship (2007/2008)
  • Kwok Ching Tong Scholarship (2004/2005)
  • Wu Chung Scholarship (2003/2004)
  • Ho Tim Scholarship (2002/2003)
  • United College Endowment Fund Prize, CUHK (2002/2003)
  • Dr. Gigi Choi (PDF)
  • Dr. Peng ZHOU (PDF)
  • Dr. Athena CHU (PDF)
  • Dr. Zhang CHU (PDF)
  • Mr. Feng XU (PhD student)
  • Ms. Chaya YUEN (MPhil student)
  • Mr. John FONG (MPhil student)
  • Ms. Becky CHAN (Research Assistant)
  • Ms. Dawn THEAN (Research Assistant)
  • Mr. Charles CHAN (Research Assistant)
  • Ms. Bei WANG (Research Assistant)
  • Ms. Cindy TONG (Technical Officer)
  • Ms. Cynthia KWOK (Technical Officer)

Last updated: July 2, 2020