Dr GAO, Bo 高波
- BSc, PhD (Shanghai Jiao Tong U)
- Assistant Professor
- Cell Signaling in Development and Disease
- B.Sc. Shanghai Jiao Tong University
- Ph.D. Shanghai Jiao Tong University
- Research Associate, The University of Hong Kong
- Postdoctoral Fellow, National Human Genome Research Institute, NIH
- Research Fellow, National Human Genome Research Institute, NIH
- Staff Scientist, National Human Genome Research Institute, NIH
Dr. Gao obtained his bachelor and doctoral degrees from Shanghai Jiao Tong University (SJTU) in Shanghai, where he received the academic training in the fields of human genetics and developmental genetics. After completing his postdoctoral training at National Human Genome Research Institute (NHGRI), National Institutes of Health (NIH), he worked in the same institute as research fellow and staff scientist. In 2015, Dr. Gao joined The University of Hong Kong as Assistant Professor.
Cell signaling is a major strategy that all living beings take to control basic cellular activities and coordinate their actions across tissues and organs. It plays fundamental roles in development, physiology and homeostasis by spatial and temporal coordination of cell proliferation, differentiation, survival and polarity. Our laboratory is interested in understanding the molecular mechanism of how Wnt signaling regulates Planar Cell Polarity (PCP), which is an evolutionarily conserved essential mechanism that provides directional information to control and coordinate polarized cellular and tissue behavior. Dysregulation of Wnt/PCP signaling underlies neural tube defects, skeletal dysplasias, neurological disorders and cancer metastasis. We use molecular, biochemical, cellular and genetic approaches to investigate how Wnt signals regulate PCP and their functions in both normal developmental processes and human diseases.
Our lab is also interested in studying the genetic and molecular basis of skeletal disorders. We aim to identify novel genetic risk factors and use mouse models to understand their pathogenic mechanisms.
- Gao B, Guo J, She C, Shu A, Yang M, Tan Z, Yang X, Guo S, Feng G, He L. Mutations in IHH, encoding Indian hedgehog, cause brachydactyly type A-1. Nat Genet. 2001, 28(4):386-8.
- Gao B, He L. Answering a century old riddle: brachydactyly type A1. Cell Res. 2004, 14(3):179-87.
- Gao B, Hu J, Stricker S, Cheung M, Ma G, Law KF, Witte F, Briscoe J, Mundlos S, He L, Cheah KS, Chan D. A mutation in Ihh that causes digit abnormalities alters its signalling capacity and range. Nature. 2009, 30;458(7242):1196-200.
- Song H, Hu J, Chen W, Elliott G, Andre P, Gao B, Yang Y. Planar cell polarity breaks bilateral symmetry by controlling ciliary positioning. Nature. 2010, 466(7304):378-82.
- Scott CE, Wynn SL, Sesay A, Cruz C, Cheung M, Gaviro MG, Booth S, Gao B, Cheah KS, Lovell-Badge R, Briscoe J. SOX9 induces and maintains neural stem cells. Nature Neuroscience. 2010, 13(10): 1181-9
- Leung VY, Gao B, Leung KK, Melhado IG, Wynn SL, Au TY, Dung NW, Lau JY, Mak AC, Chan D, Cheah KS. SOX9 governs differentiation stage-specific gene expression in growth plate chondrocytes via direct concomitant transactivation and repression. PLoS Genet. 2011, 7(11):e1002356.
- Gao B, Song H, Bishop K, Elliot G, Garrett L, English MA, Andre P, Robinson J, Sood R, Minami Y, Economides AN, Yang Y. Wnt signaling gradients establish planar cell polarity by inducing Vangl2 phosphorylation through Ror2. Dev Cell. 2011, 20(2): 163-176.
- Gao B. Wnt Regulation of Planar Cell Polarity (PCP). Curr Top Dev Biol. 2012, 101:263-295.
- Gao B, Yang Y. Planar Cell Polarity in vertebrate limb morphogenesis. Curr Opin Genet Dev. 2013 Aug;23(4):438-44.
- Yang W, Garrett L, Feng D, Elliott G, Liu X, Wang N, Wong YM, Choi NT, Yang Y and Gao B. Wnt-induced Vangl2 phosphorylation is dose-dependently required for planar cell polarity in mammalian development. Cell Res. 2017 Dec;27(12):1466-1484.
- Gao B*, Ajima R, Yang W, Li C, Song H, Anderson MJ, Liu RR, Lewandoski MB, Yamaguchi TP, Yang Y*. Coordinated directional outgrowth and pattern formation by integration of Wnt5a and Fgf signaling in planar cell polarity. Development 2018 Epub ahead of print
- RGC – Early Career Scheme 2017-2020 (PI)
- RGC – General Research Fund 2017-2020 (Co-I)
- NSFC – General Program 2017-2021 (PI)
- Health and Medical Research Fund 2018-2020 (PI)
- National Excellent Postgraduate Scholarship (2001)
- Dr Cheng Yu Tung Fellowship, Hong Kong (2002)
- Shanghai Youth Science and Technology Innovation Mayor Award (2003)
- Second-Class Prize of National Natural Science Award (2003)
- National Youth Science and Technology Innovation Award (2004)
- Nomination Award of National Excellent Doctoral Dissertation (2008)
- NIH The Fellows Award for Research Excellence (FARE) (2010)
- NHGRI Intramural Research Training Award (2012)
- NIH Genome Recognition of Employee Accomplishments and Talents (GREAT) Award (2013 & 2014)
- CHOI Nga Ting Vanessa (Technician)
- YANG Wei (PhD student, 2015 - )
- WANG Ni (PhD student, 2015 - )
- FENG Di (PhD student, 2016 - )
- LIN Xiaochen (PhD student, University Postgraduate Fellowship Awardee, 2017 - )
- JE Shun Hang (PhD student, Hong Kong PhD Fellowship Awardee, 2017 - )