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Academic Staff

Dr MA, Stephanie Kwai Yee 馬桂宜

Dr MA, Stephanie Kwai Yee 馬桂宜

  • BSc, MSc (UBC); PhD (HKU)
  • Associate Professor
L1-47, Laboratory Block, 21 Sassoon Road, Hong Kong
+852 3917 9238 (office); 3917 9424 (Lab)
+852 2817 0857
  • Exploiting Stemness as a Cancer Cell Vulnerability

  • B.Sc., The University of British Columbia, Vancouver, Canada (1996-2000)
  • M.Sc., The University of British Columbia, Vancouver, Canada (2000-2003)
  • Ph.D., The University of Hong Kong, Hong Kong (2005-2007)
  • Postdoctoral Fellow, The University of Hong Kong, Hong Kong (2007-2009)
  • Research Assistant Professor, The University of Hong Kong, Hong Kong (2009-2012)
  • Assistant Professor, Department of Clinical Oncology, The University of Hong Kong, Hong Kong (2012-2013)
  • Assistant Professor, School of Biomedical Sciences, The University of Hong Kong, Hong Kong (2013-2018)
  • Principal Investigator, State Key Laboratory for Liver Research, HKU
  • Founding Member, The Hong Kong Young Academy of Sciences

We are interested in understanding the general mechanism of tumorigenesis and developing strategies to prevent cancer through gaining new knowledge of the biological and molecular characteristics of cancer stem cells / tumor-initiating cells that are likely associated with the unfavorable outcome of this disease. Gastrointestinal tumor types particularly prevalent in Southeast Asia and Hong Kong, including hepatocellular carcinoma and esophageal squamous cell carcinoma, are currently used as model systems in our studies. Efforts are directed at conducting basic studies using a combination of molecular, cellular, OMICs, and disease modeling approaches, with an ultimate goal to translate the findings in the lab into better patient care in the clinic.

  • Ranked by ISI Essential Science Indicators as one of the top 1% most cited scholars in ‘Clinical Medicine’ and ‘All Fields” since 2010.
  • Published >70 articles

^corresponding author

  1. Ma S, Chan KW, Hu L, Lee TK, Wo JY, Ng IO, Zheng BJ, Guan XY^. Identification and characterization of tumorigenic liver cancer stem/progenitor cells. Gastroenterology 2007; 132:2542-56. [Citations: >1020]
  2. Ma S, Lee TK, Zheng BJ, Chan KW, Guan XY^. CD133+ HCC cancer stem cells promote chemoresistance by preferential expression of the Akt/PKB survival pathway. Oncogene 2008; 27:1749-58. [Citations: >635] (F1000 Rating: 8 Must Read; Mishra L: 2008.
  3. Ma S^, Tang KH, Chan YP, Lee TK, Kwan PS, Castilho A, Ng IO, Man K, Wong N, To KF, Zheng BJ, Lai PB, Lo CM, Chan KW^, Guan XY^. miR-130b promotes CD133+ liver tumor-initiating cell growth and self-renewal via tumor protein 53-induced nuclear protein 1. Cell Stem Cell 2010; 7:694-707. [Citations: >290] (Awarded the 2011 Outstanding Research Output Award, Faculty of Medicine, HKU)
  4. Tang KH, Ma S^, Lee TK, Chan YP, Kwan PS, Tong CM, Ng IO, Man K, To KF, Lai PB, Lo CM, Guan XY^, Chan KW^. CD133(+) liver tumor-initiating cells promote tumor angiogenesis, growth, and self-renewal through neurotensin/interleukin-8/CXCL1 signaling. Hepatology 2012; 55:807-20.
  5. Ma S, Bao JY, Kwan PS, Chan YP, Tong M, Fu L, Zhang N, Tong AH, Qin YR, Tsao SW, Chan KW, Lok S^, Guan XY^. Identification of PTK6, via RNA sequencing analysis, as a suppressor of esophageal squamous cell carcinoma. Gastroenterology 2012; 143:675-86.
  6. Tong M, Fung TM, Luk ST, Ng KY, Lee TK, Lin CH, Yam JW, Chan KW, Ng F, Zheng BJ, Yuan YF, Xie D, Lo CM, Man K, Guan XY, Ma S^. ANXA3/JNK signaling promotes self-renewal and tumor growth and its blockade provides a therapeutic target for hepatocellular carcinoma. Stem Cell Reports 2015; 5:45-59.
  7. Chai S, Ng KY, Tong M, Lau EY, Lee TK, Chan KW, Yuan YF, Cheung TT, Cheung ST, Wang XQ, Wong N, Lo CM, Man K, Guan XY, Ma S^. Oct4/miR-1246 signaling axis drives Wnt/β-catenin activation in liver cancer stem cells. Hepatology 2016; 64:2062-76.
  8. Ng KY, Chan LH, Chai S, Tong M, Guan XY, Lee NP, Yuan YF, Xie D, Lee TK, Dusetti NJ, Carrier A, Ma S^. TP53INP1 down-regulation activates a p73-dependent DUSP10/ERK signaling pathway to promote metastasis of hepatocellular carcinoma. Cancer Res 2017; 77:4602-12.
  9. Tong M, Che N, Zhou L, Luk ST, Kau PW, Chai S, Ngan ES, Lo CM, Man K, Ding J, Lee TK, Ma S^. Efficacy of annexin A3 blockade in sensitizing hepatocellular carcinoma to sorafenib and regorafenib. J Hepatol 2018; 69:826-39.
  10. Chan LH#, Zhou L#, Ng KY#, Wong TL#, Lee TK, Sharma R, Loong JH, Ching YP, Yuan YF, Xie D, Lo CM, Man K, Artegiani B, Clevers H, Yan HH, Leung SY, Richard S, Guan XY, Huen MS, Ma S^. Protein arginine methyltransferase PRMT6 regulates RAS/RAF binding and MEK/ERK-mediated cancer stemness activities in hepatocellular carcinoma through CRAF methylation. Cell Rep 2018; 25:690-701. #equal contribution
  11. Wong TL, Ng KY, Tan KV, Chan LH, Zhou L, Che N, Hoo RL, Lee TK, Richard S, Lo CM, Man K, Khong PL, Ma S^. CRAF methylation by PRMT6 regulates aerobic glycolysis driven hepatocarcinogenesis via ERK-dependent PKM2 nuclear relocalization and activation. Hepatology 2019; Epub ahead of print.
  12. Leung CO#, Tong M#, Chung KP, Zhou L, Che N, Tang KH, Ding J, Lau EY, Ng IO, Ma S^, Lee TK^. Overriding adaptive resistance in sorafenib via combination therapy with SHP2 blockade in hepatocellular carcinoma. Hepatology 2019; Epub ahead of print. #equal contribution
  • RGC GRF 2016/17 (PI)
  • RGC TBRS 2016/17 (Co-PI)
  • RGC TBRS 2016/17 (Co-I)
  • NSFC General Program 2016 (PI)
  • RGC GRF 2017/18 (PI)
  • HMRF 2017 (PI)
  • RGC CRF 2018/19 (PC)
  • Outstanding Young Scientist Travel Award, National Institute of Health, USA (2001)
  • Li Ka Shing Prize (for the best Ph.D. thesis in the Faculties of Dentistry, Engineering, Medicine and Science), Graduate School, HKU (2006/2007)
  • International Society for Stem Cell Research (ISSCR) Travel Award, USA (2007)
  • Hong Kong Young Scientist Award (Life Sciences), Hong Kong Institution of Science (2008)
  • State Key Laboratory for Liver Research – Young Researcher Career Development Scheme (YRCDS), HKU (2011)
  • Faculty Outstanding Research Output Award, Faculty of Medicine, HKU (2011) – in the capacity of first and corresponding author
  • Faculty Outstanding Research Output Award, Faculty of Medicine, HKU (2012) – in the capacity of co-author
  • Outstanding Young Researcher Award, HKU (2012/2013)
  • Croucher Innovation Award, The Croucher Foundation (2014)
  • Higher Education Institution of China - Scientific Research Outstanding Achievement Awards (Second-class Award in Science and Technology Section) (2014)
  • University of British Columbia (UBC) Alumni Builder Award (2017/18)
  • Ton Duc Thang University Scientific Prize – Rising Star Award, Vietnam (2018)
  • Dr. Man TONG, Carol (Research Assistant Professor)
  • Dr. Kai Yu NG, Johnson (Senior Technical Officer/Lab Manager)
  • Dr. Tin Lok WONG, Eric (Postdoctoral Fellow)
  • Dr. Lei ZHOU, Lena (Postdoctoral Fellow)
  • Dr. Chun NGAN, Chris (Postdoctoral Fellow)
  • Ms. Ho Chun LOONG, Jane (PhD Student, 2017-2021)
  • Mr. Tsz Lam WONG, Matthew (PhD Student, 2018-2021)
  • Mr. Jia Jian LOH (HKPF PhD Student, 2019-2023)
  • Ms. Ya GAO, Victoria (PhD Student, 2019-2023)
  • Ms. Yifei WANG (Research Assistant)

Last updated: October 7, 2019