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Dr SANYAL, Sumana (joint appointment with School of Public Health)

Dr SANYAL, Sumana (joint appointment with School of Public Health)

  • MSc (Indian Institute of Technology); PhD (Cornell U)
  • Assistant Professor
7/F, Jockey Club Building for Interdisciplinary Research, 5 Sassoon Road, Hong Kong
+852 2831 5524
+852 2872 5782
  • Host pathogen interactions
  • Post-translational protein regulation by ubiquitylation
  • Lipid metabolism
  • Innate immune signaling in virus infections

Dr. Sumana Sanyal is a biochemist by training with an interest in aspects of host pathogen interactions including influenza, dengue and related viruses. She obtained her PhD from Cornell University, USA and postdoctoral training from the Whitehead Institute and the Massachusetts Institute of Technology, USA.

Research in Dr Sanyal’s group includes identification and characterization of host factors important in virus pathogenesis. Using a combination of genetics and proteomics-based approaches her research group is investigating how post translational modifications, especially the ubiquitylation machinery, are targeted and alter protein function during cellular perturbations such as in virus infections, either to facilitate replication and pathogenesis or in installing a host immune response.

  1. Zhang J, Lan Y, Li MY, Lamers MM, Fusade-Boyer M, Klemm E, Thiele C, Ashour J and Sanyal S*. Flaviviruses exploit the lipid droplet protein AUP1 to trigger lipophagy and drive virus production (2018) Cell Host Microbe. 23 (6): 819-831
  2. Pombo JP and Sanyal S*. Perturbation of cholesterol and fatty acid homeostasis during flavivirus infections (2018) Front Immunol. June 4; 9: 1276
  3. Zhang J, Lan Y and Sanyal S*. Modulation of lipid droplet metabolism – a potential target for therapeutic intervention in Flaviviridae infections. (2017) Front Microbiol. Nov 28; 8: 2286
  4. Fan Y, Mok CK, Kein F, Bruzzone R* and Sanyal S*. Cell-cycle independent role of CyclinD3 in host restriction of influenza infection (2017) J Biol Chem 292(12): 5070-5088
  5. Sanyal S. Reply to Rodriguez: Mechanism of nuclear-cytosol shuttling of Usp12 (2016) Proc Natl Acad Sci USA 113(24): E3317-18
  6. Jahan AS, Lestra M, Swee LK, Fan Y, Lamers MM, Tafesse FG, Theile CS, Spooner E, Bruzzone R, Ploegh HL and Sanyal S*. Usp12 stabilizes the T-cell receptor at the cell surface during signaling (2016) Proc Natl Acad Sci USA 113(6): E705-14
    *corresponding author
  7. Lin YP, Luo Y, Chen Y, Lamers MM, Zhou Q, Yang XH, Sanyal S, Mok CK, Liu ZM. Clinical and epidemiological features of the 2014 large-scale dengue outbreak in Guanzhou city, China (2016) BMC Infect Dis 16(1): 102
  1. Research Grants Council-General Research Funds (Government of HK; 2014-2016): 
    Host factors involved in Dengue virus infection: Principal investigator
  2. Research Grants Council-General Research Funds (Government of HK; 2016-2018): 
    Role of Tsg101 in influenza virus infection: Principal investigator
  3. Health and Medical Research Funds (Government of HK; 2014-2016): 
    Development of therapeutic strategies against viral infections by targeting the host ubiquitylation machinery and its modulation of the innate immune response: Principal Investigator
  4. Health and Medical Research Funds (Government of HK; 2015 recommended for support)
  5. Institut Pasteur Programmes Transversaux De Recherche (PTR) (2015-2017): 
    Deciphering influenza virus polymerase interplay with the ubiquitin proteasome system during pathogenesis: Principal investigator
  6. University of Hong Kong Seed Funding Programme for basic research (2014-2016): Principal Investigator
  7. Area of Excellence for Influenza Research (2014-2016): Co-Investigator
  8. Research Grants Council-General Research Funds (Government of HK; 2014/2015): 
    Viral Host and Environmental determinants of Influenza virus transmission and pathogenesis: Co-investigator