Date: 8 June 2026 (Monday)
Time: 10:00 am – 11:00 am
Venue: Seminar Room 2, G/F, Laboratory Block, 21 Sassoon Road 
Host: Professor Tao Ni

Dr. Yang is currently a senior cryoCLEM specialist in the European Molecular Biology Organisation (EMBO). He obtained his PhD in Physics in 2014 in the University of Dundee working on optical imaging, where he continued to work as a research fellow until 2017. After that he moved to Oxford, working in the National electron microscopy imaging centre (eBIC) until 2020, before joining EMBO. Dr Yangs current interest and expertise lies in the biological cryo-CLEM and tomography and has been dedicated to developing novel image acquisition and workflows to EMBL Imaging Center.

Cryogenic correlative light and electron microscopy (cryoCLEM) and cryo-electron tomography (cryoET) enable structural studies of biological specimens in their native cellular context. At the EMBL Imaging Centre, we provide integrated cryoCLEM/ET workflows spanning sample preparation, vitrification, cryogenic fluorescence imaging, FIB milling, and TEM data acquisition. In this presentation, we highlight practical best practices developed through routine service operation, including optimized sample carriers, efficient screening strategies, improved cryo-FIB milling / cryo-liftout procedures, fluorescence-correlation workflows, and automated data collection pipelines. These approaches enhance targeting accuracy, throughput, reproducibility, and data quality, supporting reliable high-throughput in situ structural biology.

All are welcome.