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Principal Investigators

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Cheung, Lydia Wai Ting

  • Functional genomics for translational cancer medicine
  • Cancer biology

Gao, Bo  

  • Cell signaling in development and disease

He, Mu

  • Development and regeneration of the respiratory system 
  • Airway mucus and cilia interaction 
  • Airway organoid platforms for human disease modeling

Hervas Millan, Rubén

  • Biophysics and protein structure
  • Protein aggregation in physiological processes
  • Structure and activity of functional amyloids

Javed, Asif

  • Multi-omics analysis of cancers and rare diseases
  • Computational biology

Kim, Jung

  • Systemic tumor-host interactions
  • Paraneoplastic syndromes
  • Tumor-dependent stem cell dysregulation
  • Stress-induced blood-brain barrier damage

Kwon, Sung Chul

  • IRNA biology and genome engineering

Lee, Chi Wai

  • Intracellular trafficking of proteins and organelles
  • Cytoskeletal dynamics in neuronal motility
  • Pathogenesis of muscular dystrophy

Lim, Lee Wei

  • Deep brain stimulation in neurological and neuropsychiatric diseases
  • Behavioral, cellular and molecular neurosciences

Ling, Guang Sheng Heidi

  • Metabolic reprogramming of CD8T cells in chronic inflammatory diseases

Liu, Yang

  • How epigenetic markers on chromatin are regulated by histone chaperones and chromatin remodelers

Ni, Tao

  • Host – pathogen interaction
  • Pore-forming proteins
  • Macromolecule assembly mechanism
  • Cryo-electron tomography and subtomogram averaging

Shih, David Jen Hao

  • Cancer genomics and somatic evolution
  • Bayesian statistical modeling of complex biological data
  • Deep learning for computational biology and medicine

Sugimura, Rio Ryohichi

  • Innate Immunity
  • Cancer Immunotherapy
  • Organoids & Stem Cells

Ti, Shih Chieh Jeff

  • The regulation of microtubule cytoskeleton

Yu, Cheng-Han

  • Integrin signaling in cell-matrix adhesion
  • Lipid signaling in podosomes and invadopodia
  • Mechanobiology and cancer metastasis
  • Advanced fluorescence microscopy and image analysis
  • Bio-functionalized supported lipid membrane

Zhou, Keda

  • Chromatin higher order structures
  • Factors modulating chromatin structures during transcription
  • Structure and dynamics of large molecular machines in DNA related processes

Chan, Vera Sau Fong (joint appointment with Department of Medicine)

  • Innate receptors immunobiology: C-type lectin receptors and Toll-like receptors and their roles in autoimmune diseases and infection
  • Cellular immuno-dysregulation in systemic lupus erythematosus
  • Molecular profiling and biomarkers development for SLE
  • Molecular and cellular immunology; animal models for autoimmune diseases

Chu, Zhiqin (joint appointment with Department of Electrical and Electronic Engineering)

  • Precision biosensing/imaging (e.g., Spin defects in diamond for bio-oriented quantum sensing)
  • Biophysics
  • Biophotonics and materials-biology interface

Chung, Yik Sham Clive (joint appointment with Department of Pathology)

  • Chemical biology
  • Organic synthesis of novel functional tools and drug lead compounds for biological studies and diease therapy
  • Chemoproteomics and mass spectrometry (MS)
  • Molecular imaging of cellular signaling molecules

Huang, Yuanhua (joint appointment with Department of Statistics and Actuarial Science)

  • Bioinformatics
  • Single-cell genomics
  • RNA splicing
  • Cancer evolution
  • Statistical modelling
  • Machine learning

Wong, Alan Siu Lun (joint appointment with Department of Electrical and Electronic Engineering)

  • Combinatorial genetics
  • Genome engineering
  • Protein engineering
  • Synthetic biology
  • Disease biology
  • Combination therapy