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Jan 03, 2020

RPG Seminar Series (Speaker: Miss. Gong Huarui)

Date: Friday, 3 January 2020

Venue: Seminar Room 1, G/F
Laboratory Block, Faculty of Medicine Building
21 Sassoon Road, Hong Kong

Time: 5:00 p.m.

Title: The identification of the anti-cancer metastasis components in Salmonella (YB1)-treated mice serum
Speaker: Miss. Gong Huarui (PhD candidate)


Metastatic tumors spread to different organs and are the primary cause of death in cancer patients. Hindering invasive and migratory capability of tumor cells can offer new approaches to treat patients with malignant cancer.

Previous work in our lab has shown that our engineered Salmonella strain YB1 possesses potent anti-metastasis effect in multiple mouse tumor models. Interestingly, we observed that the engineered Salmonella-treated mice serum can remarkably inhibit the migration of murine breast cancer cell 4T1 in vitro. However, the underlying mechanisms of this effect remain unclear.

To identify the factors in Salmonella-treated mice serum that exert the anti-metastasis effect on cancer cells, we have applied chromatography methods to isolate and purify protein fractions from mice serum, and then further identified several promising candidate proteins that may inhibit migration of cancer cells by mass spectrometry. Next step, I sought to validate the anti-metastasis effect of these candidate proteins both in vitro and in vivo.