Publication List

2012

  1. Cheung KMC, Samartzis D, Karppinen J, Luk KDK. 2012. Are patterns  of disc degeneration of the lumbar spine associated with low back pain? New insights based on skipped level pathology. Spine [Epub ahead of print]
  2. Fan YH, Song YQ, Chan D, Takahashi Y, Ikegawa S, Matsumoto M, Kou I, Cheah KSE, Sham P, Cheung KMC, Luk KD. 2012. SNP rs11190870 near LBX1 is associated with adolescent idiopathic scoliosis in southern Chinese. J Hum Genet [Epub ahead of print].
  3. Matheu A, Collado M, Wise C, Manterola L, Cekaite L, Tye AJ, Canamero M, Bujanda L, Schedl A, Cheah KSE, Skotheim RI, Lothe RA, López de Munain A, Briscoe J, Serrano M, Lovell-Badge R. 2012. Oncogenicity of the Developmental Transcription Factor Sox9. Cancer Res. 72:1301-15
  4. Samartzis D, Karppinen J, Chan D, Luk KDK, Cheung KMC. 2012. The association of lumbar intervertebral disc degeneration on MRI in overweight and obese adults: a population-based study. Arthr Rheum [Epub ahead of print]
  5. Wang C, Shang Y, Yu J, Zhang M. 2012. Substrate recognition mechanism of atypical protein kinase Cs revealed by the structure of PKCι in complex with a substrate peptide from Par-3. Structure (In Press)
  6. Yuan Q, Su H, Guo J, Tsang KY, Cheah KSE, Chiu K, Yang J, Wong WM, So KF, Huang JD, Wu W, Lin ZX. 2012. Decreased c-Jun expression correlates with impaired spinal motoneuron regeneration in aged mice following sciatic nerve crush. Exp. Gerontol. 47(4):329-36

2011

  1. Chan W, Sze KL, Samartzis D, Leung V, Chan D. 2011. Structure and biology of the intervertebral disc in health and disease. Orthop. Clin. North. Am. 42:447-64
  2. Kao P, Chan D, Samartzis D, Sham P, Song Y-Q. 2011. Genetics of lumbar disc degeneration: technology, study designs, and risk factors. Orthop. Clin. North. Am. 42:479-86
  3. Karppinen J, Shen FH, Luk KDK, Andersson GBJ, Cheung KMC, Samartzis D. 2011. Management of degenerative disc disease and chronic low back pain. Orthop. Clin. North. Am. 42:513-28
  4. Leung VYL, Gao B, Leung KKH, Melhado I, Wynn SL, Au TYK, Dung NWF, Lau JYB, Mak ACY, Chan D, Cheah KSE. 2011. Sox9 governs differentiation stage-specific gene expression in growth plate chondrocytes via direct concomitant transactivation and repression. PLoS Genetics 7(11): e1002356
  5. Ma G, Yu J, Xiao Y, Chan D, Gao B, Hu J, He Y, Guo S, Zhou J, Zhang L, Gao L, Zhang W, Kang Y, Cheah KSE, Feng G, Guo X, Wang Y, Zhou CZ, He L. 2011. Indian hedgehog mutations causing brachydactyly type A1 impair Hedgehog signal transduction at multiple levels. Cell Research 21(9):1343-57
  6. Pan L, Chen J, Yu J, Yu H, Zhang M. 2011.The structure of the PDZ3-SH3-GuK tandem of ZO-1 protein suggests a supramodular organization of the membrane-associated guanylate kinase (MAGUK) family scaffold protein core. J Biol Chem. 286:40069-74
  7. Samartzis D, Karppinen J, Mok FPS, Fong DYT, Luk KDK, Cheung KMC. 2011. A population-based study of juvenile disc degeneration and its association with overweight and obesity, low back pain, and diminished functional status. J. Bone Joint Surg. Am. 93: 662-70
  8. Shum KT, Chan C, Leung CM, Tanner JA. 2011. Identification of a DNA aptamer that inhibits sclerostin's antagonistic effect on Wnt signaling. Biochem J. 434: 493-501
  9. Tanner JA, Shum KT, Chan CSL. 2011. High-affinity nucleic acid aptamers against sclerostin protein. US and PCT Patent, WO2011/147193
  10. Wang LY, Wang PW, Li MJ, Qin J, Wang XW, Zhang MQ, and Wang JW. 2011. EpiRegNet: constructing epigenetic regulatory networks from high throughput gene expression data for human. Epigenetics 6(12):1505-12
  11. Wu XG, Zong M, Chan CWL, Choi MY, Chan HC, Tanner JA, Yu S. 2011. The adaptor function of TRAPPC2 in mammalian TRAPPs explains TRAPPC2-associated SEDT and TRAPPC9-associated congenital intellectual disability. PLoS ONE 6(8):e23350
  12. Yang S, Yalamanchili HK, Li X, Yao KM, Sham PC, Zhang MQ, Wang JW. 2011 . Correlated evolution of transcription factors and their binding sites. Bioinformatics 27:2972-78
  13. Zhu J, Shang Y, Xia C, Wang W, Wen W, Zhang M. 2011. Guanylate Kinase Domains of the MAGUK Family Scaffold Proteins as Specific Phospho-Protein Binding Modules. EMBO J 30: 4986-97

2010

  1. Aladin DMK, Cheung KMC, Ngan AHW, Chan D, Leung VYL, Lim CT, Luk KDK, Lu WW. 2010. Nanostructure of collagen fibrils in human nucleus pulposus and its correlation with macroscale tissue mechanics. J. Orthop. Res. 28: 497-502
  2. Cheung KMC, Samartzis D, Karppinen J, Mok FPS, Ho DWH, Fong DYT, Luk KDK. 2010. Intervertebral disc degeneration: new insights based on "skipped" level disc pathology. Arthritis Rheum. 62: 2392-400
  3. Garcia-Barcelo MM, Yeung MY, Miao XP, Tang CSM, Chen G, So MT, Ngan ESW, Lui VCH, Chen Y, Liu XL, Hui K, Li L, Guo WH, Sun XB, Tou JF, Chan KW, Wu XZ, Song YQ, Chan D, Cheung K, Chung PHY, Wong KKY, Sham PC, Cherny SS, Tam PKH. 2010. Genome-wide association study identifies a susceptibility locus for biliary atresia on 10q24.2. Hum. Mol. Genet. 19: 2917-25
  4. Guo JJ, Luk KDK, Karppinen J, Yang HL, Cheung KMC. 2010. Prevalence, distribution, and morphology of ossification of the ligamentum flavum: a population study of one thousand seven hundred thirty-six magnetic resonance imaging scans. Spine 35: 51-56
  5. Guo SZ, Zhou J, Gao B, Hu JX, Wang HS, Meng JW, Zhao XZ, Ma G, Lin CW, Xiao Y, Tang W, Zhu XM, Cheah KSE, Feng GY, Chan D, He L. 2010. Missense mutations in IHH impair Indian Hedgehog signaling in C3H10T1/2 cells: Implications for brachydactyly type A1, and new targets for Hedgehog signaling. Cell. Mol. Biol. Lett. 15: 153-76
  6. Li MJ, Sham PC, Wang JW. 2010. FastPval: a fast and memory efficient program to calculate very low p-values from empirical distribution. Bioinformatics.  26:2897-99
  7. Mok FPS, Samartzis D, Karppinen J, Luk KDK, Fong DYT, Cheung KMC. 2010. ISSLS prize winner: Prevalence, determinants, and association of Schmorl nodes of the lumbar spine with disc degeneration: a population-based study of 2449 individuals. Spine 35: 1944-52
  8. Thomsen MK, Ambroisine L, Wynn S, Cheah KSE, Foster CS, Fisher G, Berney DM, Moller H, Reuter VE, Scardino P, Cuzick J, Ragavan N, Singh PB, Martin FL, Butler CM, Cooper CS, Swain A, Transatlantic Prostate Group. 2010. SOX9 elevation in the prostate promotes proliferation and cooperates with PTEN loss to drive tumor formation. Cancer Res. 70: 979-87
  9. Tsang KY, Cheung MCH, Chan D, Cheah KSE. 2010. The developmental roles of the extracellular matrix: beyond structure to regulation. Cell Tissue Res. 339: 93-110
  10. Tsang SW, Shao D, Cheah KSE, Okuse K, Leung PS, Yao KM. 2010. Increased basal insulin secretion in Pdzd2-deficient mice. Mol. Cell. Endocrinol. 315: 263-70
  11. Wen WY, Yu J, Pan LF, Wei ZY, Weng JW, Wang WN, Ong YS, Tran THT, Hong WJ, Zhang MJ. 2010. Lipid-Induced conformational switch controls fusion activity of longin domain SNARE Ykt6. Mol. Cell 37: 383-95
  12. Yang L, Hui WS, Chan WCW, Ng VCW, Yam THY, Leung HCM, Huang JD, Shum DKY, Jie QA, Cheung KMC, Cheah KSE, Luo ZJ, Chan D. 2010. A splice-site mutation leads to haploinsufficiency of EXT2 mRNA for a dominant trait in a large family with multiple osteochondromas. J. Orthop. Res. 28: 1522-30

2009

  1. Cheung KMC, Karppinen J, Chan D, Ho DWH, Song YQ, Sham P, Cheah KSE, Leong JCY, Luk KDK. 2009. Prevalence and pattern of lumbar magnetic resonance imaging changes in a population study of one thousand forty-three individuals. Spine 34: 934-40
  2. Choi MY, Chan CCY, Chan D, Luk KDK, Cheah KSE, Tanner JA. 2009. Biochemical consequences of sedlin mutations that cause spondyloepiphyseal dysplasia tarda. Biochem. J. 423: 233-42
  3. Gao B, Hu JX, Stricker S, Cheung M, Ma G, Law KF, Witte F, Briscoe J, Mundlos S, He L, Cheah KSE, Chan D. 2009. A mutation in Ihh that causes digit abnormalities alters its signalling capacity and range. Nature 458: 1196-200
  4. Garcia-Barcelo MM, Tang CSM, Ngan ESW, Lui VCH, Chen Y, So MT, Leon TYY, Miao XP, Shum CKY, Liu FQ, Yeung MY, Yuan ZW, Guo WH, Liu L, Sun XB, Huang LM, Tou JF, Song YQ, Chan D, Cheung KMC, Wong KKY, Cherny SS, Sham PC, Tam PKH. 2009. Genome-wide association study identifies NRG1 as a susceptibility locus for Hirschsprung's disease. Proc. Natl. Acad. Sci. U. S. A. 106: 2694-99
  5. Leung VYL, Chan WCW, Hung SC, Cheung KMC, Chan D. 2009. Matrix remodeling during intervertebral disc growth and degeneration detected by multichromatic FAST staining. J. Histochem. Cytochem. 57: 249-56
  6. Li MX, Jiang L, Kao PYP, Sham PC, Song YQ. 2009. IGG3: a tool to rapidly integrate large genotype datasets for whole-genome imputation and individual-level meta-analysis. Bioinformatics 25: 1449-50
  7. Shao D, Baker MD, Abrahamsen B, Rugiero F, Malik-Hall M, Poon WYL, Cheah KSE, Yao KM, Wood JN, Okuse K. 2009. A multi PDZ-domain protein Pdzd2 contributes to functional expression of sensory neuron-specific sodium channel Na(V)1.8. Mol. Cell. Neurosci. 42: 219-25
  8. Tang PLF, Cheung CL, Shan PC, McClurg P, Lee B, Chan SY, Smith DK, Tanner JA, Su AI, Cheah KSE, Kung AWC, Song YQ. 2009. Genome-wide haplotype association mapping in mice identifies a genetic variant in CER1 associated with BMD and fracture in southern Chinese women. J. Bone Miner. Res. 24: 1013-21
  9. Wei F, Zaprazna K, Wang JW, Atchison ML. 2009. PU.1 can recruit BCL6 to DNA to repress gene expression in germinal center B cells. Mol. Cell. Biol. 29: 4612-22
  10. Yeung CW, Cheah K, Chan D, Chan BP. 2009. Effects of reconstituted collagen matrix on fates of mouse embryonic stem cells before and after induction for chondrogenic differentiation. Tissue Eng. Part A 15: 3071-85

2008

  1. Chen J, Pan LF, Wei ZY, Zhao YX, Zhang MJ. 2008. Domain-swapped dimerization of ZO-1 PDZ2 generates specific and regulatory connexin43-binding sites. EMBO J. 27: 2113-23
  2. Cheung KMC, Al Ghazi S. 2008. Current understanding of low back pain and intervertebral disc degeneration: epidemiological perspectives and phenotypes for genetic studies. Curr. Orthop. 22: 237-44
  3. Cheung KMC, Ito K. 2008. World Forum for Spine Research: The intervertebral disc. Eur. Spine J. 17: S419-S20
  4. Ho DWH, Chan D, Cheung KMC, Sham P, Song YQ. 2008. Family-based linkage and case control association studies. Curr. Orthop. 22: 245-50
  5. Li MX, Jiang L, Song YQ, Sham PC. 2008. Power of transmission/disequilibrium tests in admixed populations. Genet. Epidemiol. 32: 434-44
  6. Long JF, Wei ZY, Feng W, Yu C, Zhao YX, Zhang MJ. 2008. Supramodular nature of GRIP1 revealed by the structure of its PDZ12 tandem in complex with the carboxyl tail of Fras1. J. Mol. Biol. 375: 1457-68
  7. Sham PC, Cherny SS, Kao PYP, Song YQ, Chan D, Cheung KMC. 2008. Whole-genome association studies of complex diseases. Curr. Orthop. 22: 251-58
  8. Song YQ, Cheung KMC, Ho DWH, Poon SCS, Chiba K, Kawaguchi Y, Hirose Y, Alini M, Grad S, Yee AFY, Leong JCY, Luk KDK, Yip SP, Karppinen J, Cheah KSE, Sham P, Ikegawa S, Chan D. 2008. Association of the asporin D14 allele with lumbar-disc degeneration in Asians. Am. J. Hum. Genet. 82: 744-47
  9. Song YQ, Ho DWH, Karppinen J, Kao PYP, Fan BJ, Luk KDK, Yip SP, Leong JCY, Cheah KSE, Sham P, Chan D, Cheung KMC. 2008. Association between promoter-1607 polymorphism of MMP1 and lumbar disc disease in Southern Chinese. BMC Med. Genet. 9: 38
  10. Song YQ, Sham P, Cheung KMC, Chan D. 2008. Genetics of disc degeneration. Curr. Orthop. 22: 259-66
  11. Yin Y, Yu VC, Zhu G, Chang DC. 2008. SET8 plays a role in controlling G1/S transition by blocking lysine acetylation in histone through binding to H4 N-terminal tail. Cell Cycle 7: 1423-32
  12. Zhou GQ, Yang F, Leung VVL, Cheung KMC. 2008. Molecular and cellular biology of the intervertebral disc and the use of animal models. Curr. Orthop. 22: 267-73

2007

  1. Aladin DMK, Cheung KMC, Chan D, Yee AFY, Jim JJT, Luk KDK, Lu WW. 2007. Expression of the Trp2 allele of COL9A2 is associated with alterations in the mechanical properties of human intervertebral discs. Spine 32: 2820-26
  2. Chang DC. 2007. Using biophotonics to study signaling mechanisms in a single living cell. Int. J. Mod. Phys. B 21: 4091-103
  3. Ho MSP, Tsang KY, Lo RLK, Susic M, Makitie O, Chan TWY, Ng VCW, Sillence DO, Boot-Handford RP, Gibson G, Cheung KMC, Cole WG, Cheah KSE, Chan D. 2007. COL10A1 nonsense and frame-shift mutations have a gain-of-function effect on the growth plate in human and mouse metaphyseal chondrodysplasia type Schmid. Hum. Mol. Genet. 16: 1201-15
  4. Tsang KY, Chan D, Cheslett D, Chan WCW, So CL, Melhado IG, Chan TWY, Kwan KM, Hunziker EB, Yamada Y, Bateman JF, Cheung KMC, Cheah KSE. 2007. Surviving endoplasmic reticulum stress is coupled to altered chondrocyte differentiation and function. PLoS Biol. 5: 568-85
  5. Virtanen IM, Song YQ, Cheung KMC, Ala-Kokko L, Karppinen J, Ho DWH, Luk KDK, Yip SP, Leong CY, Cheah KSE, Sham P, Chan D. 2007. Phenotypic and population differences in the association between CILP and lumbar disc disease. J. Med. Genet. 44: 285-88
  6. Yeung MY, Smith DK, Chan MSY, Li CM, Wong BC, Cheung KMC, Luk KDK, Cheah KSE, Sham P, Chan D, Song YQ. 2007. iCartiGD: the integrated cartilage gene database. BMC Genet. 8: 4

2006

  1. Chan D, Song Y, Sham P, Cheung KMC. 2006. Genetics of disc degeneration. Eur. Spine J. 15: S317-S25
  2. Cheung KMC, Chan D, Karppinen J, Chen YQ, Jim JJT, Yip SP, Ott J, Wong KK, Sham P, Luk KDK, Cheah KSE, Leong JCY, Song YQ. 2006. Association of the Taq I allele in vitamin D receptor with degenerative disc disease and disc bulge in a Chinese population. Spine 31: 1143-48

2005

  1. Chang DC, Zhou LY, Luo KQ. 2005. Using GFP and FRET technologies for studying signaling mechanisms of apoptosis in a single living cell. In Biophotonics: Optical Science and Engineering for the 21st Century, ed. X Shen, R Van Wijk, pp. 25-38. New York: Springer
  2. Guo J, Pu YM, Chang DC. 2005. Calcium signaling in apoptosis. Acta Biophys. Sinica 21: 1-18
  3. Jim JJT, Noponen-Hietala N, Cheung KMC, Ott J, Karppinen J, Sahraravand A, Luk KDK, Yip SP, Sham PC, Song YQ, Leong JCY, Cheah KSE, Ala-Kokko L, Chan D. 2005. The TRP2 allele of COL9A2 is an age-dependent risk factor for the development and severity of intervertebral disc degeneration. Spine 30: 2735-42
  4. Liu BH, Wang JM, Chan KM, Tjia WM, Deng W, Guan XY, Huang JD, Li KM, Chau PY, Chen DJ, Pei DQ, Pendas AM, Cadinanos J, Lopez-Otin C, Tse HF, Hutchison C, Chen JJ, Cao YH, Cheah KSE, Tryggvason K, Zhou ZJ. 2005. Genomic instability in laminopathy-based premature aging. Nat. Med. 11: 780-85
  5. Varela I, Cadinanos J, Pendas AM, Gutierrez-Fernandez A, Folgueras AR, Sanchez LM, Zhou ZJ, Rodriguez FJ, Stewart CL, Vega JA, Tryggvason K, Freije JMP, Lopez-Otin C. 2005. Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation. Nature 437: 564-68
  6. Wilson R, Freddi S, Chan D, Cheah KSE, Bateman JF. 2005. Misfolding of collagen X chains harboring Schmid metaphyseal chondrodysplasia mutations results in aberrant disulfide bond formation, intracellular retention, and activation of the unfolded protein response. J. Biol. Chem. 280: 15544-52
  7. Zhou LL, Zhou LY, Luo KQ, Chang DC. 2005. Smac/DIABLO and cytochrome c are released from mitochondria through a similar mechanism during UV-induced apoptosis. Apoptosis 10: 289-99