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Press Release: HKUMed identifies a new pathway to prevent invasive cell migration of cancer cells by blocking PI(3,4)P2 lipid synthesis and receptor recycling

Press Release: HKUMed identifies a new pathway to prevent invasive cell migration of cancer cells by blocking PI(3,4)P2 lipid synthesis and receptor recycling

A research team of cell biologist in LKS Faculty of Medicine, The University of Hong Kong (HKUMed) has discovered how to impede invasive cell migrations by blocking the synthesis of PI(3,4)P2 lipids that are excessively produced in cancer cells. By the inhibition of PI(3,4)P2 synthesis, invasive cell migrations are effectively suppressed in various models, including in the triple-negative breast cancer cell line. This study has revealed a druggable target to suppress cancer metastasis, the malignant spread of cancer cells, which ranks highest in the cause of health-related mortality in Hong Kong1. The findings have been published in Proceedings of the National Academy of Sciences of the United States of America (PNAS).

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Press Release: HKUMed researchers unveil a novel molecular mechanism underlying liver cancer drug resistance and tumour recurrence

Press Release: HKUMed researchers unveil a novel molecular mechanism underlying liver cancer drug resistance and tumour recurrence

Researchers at the LKS Faculty of Medicine, The University of Hong Kong (HKUMed) have uncovered a novel signalling pathway triggered by a protein called FUT1 to promote cancer stemness, contributing to drug resistance and tumour recurrence of liver cancer cells. The findings are now published in The Journal of Clinical Investigation (J Clin Invest).

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Media Coverage: Dr Stephanie Ma shared in an interview on Topick

Media Coverage: Dr Stephanie Ma shared in an interview on Topick

Dr Stephanie Ma shared her experience and the journey of study in an interview on Topick.

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Press Release: HKUMed identifies Collagen IV differentially regulates planarian stem cell potency and lineage progression: Striving towards tissue regeneration in humans

Press Release: HKUMed identifies Collagen IV differentially regulates planarian stem cell potency and lineage progression: Striving towards tissue regeneration in humans

A research team of LKS Faculty of Medicine, The University of Hong Kong (HKUMed) has identified a role of an extracellular matrix protein (ECM), Collagen IV, in the regulation of pluripotent stem cells in the regenerative flatworm (planarian). This collagen plays an important role in regulating how stem cells divide or change in the planarian, crucial to its regenerative capacity and can improve our understanding of human tissue regeneration. This study has been published in Proceedings of the National Academy of Sciences of the United States of America (PNAS). 

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Event: Croucher Science Week 2021

Event: Croucher Science Week 2021

Ms. Jane Loong and Mr. Matthew Wong, two PhD students of Dr Stephanie Ma' Lab, have participated in the Croucher Science Week 2021 via making two videos on "Who Stole My Snacks" and "A Day in the Life of a Biologist".

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Press Release: HKUMed research team reveals a novel epigenetic mechanism in rRNA transcriptional regulation and raises new possibility of targeted therapy for cancer treatment

Press Release: HKUMed research team reveals a novel epigenetic mechanism in rRNA transcriptional regulation and raises new possibility of targeted therapy for cancer treatment

A research team at the School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong (HKUMed) identified a stable Spindlin1/C11orf84 protein complex preferentially recognises a non-canonical bivalent histone H3K4me3K9me3 mark and promotes rRNA transcription.

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Media Coverage: Prof. Danny Chan's study picked on Biomedical Picture of the Day (BPoD)

Media Coverage: Prof. Danny Chan's study picked on Biomedical Picture of the Day (BPoD)

Prof. Danny Chan's study on eLife was picked on Biomedical Picture of the Day (BPoD), MRC London Institute of Medical Sciences. 

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Media Coverage: Prof. DY Jin at the interview in TVB

Media Coverage: Prof. DY Jin at the interview in TVB

Prof. DY Jin was interviewed by TVB to talk about COVID-19 and the vaccine.

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Media Coverage: Dr Lai Kwok On's study featured at Croucher Science Week's Blog

Media Coverage: Dr Lai Kwok On's study featured at Croucher Science Week's Blog

A research team led by Dr Lai Kwok On (Croucher Fellowship 2003) at the University of Hong Kong has uncovered a previously uncharacterised function of the TBC1D24 gene in the maintenance of neuronal connections in the brain, a discovery that could eventually lead to new therapeutic pathways for patients suffering from epilepsy and intellectual disability.

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Media Coverage: Dr Alan Wong at the interview in Sing Tao Daily

Media Coverage: Dr Alan Wong at the interview in Sing Tao Daily

港大醫學院生物醫學學院助理教授黃兆麟指出,基因編輯經歷多年演化,已從過去局限於剪除變異的基因,發展至可以改變錯誤的基因序列,令治療手段更多元,可應付目前無藥可醫的遺傳病,故他專注於提升技術的準確性及效率,冀盡早為病人帶來曙光。

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