Press Release: HKUMed identifies a new pathway to prevent invasive cell migration of cancer cells by blocking PI(3,4)P2 lipid synthesis and receptor recycling
Jun 01, 2021
A research team of cell biologist in LKS Faculty of Medicine, The University of Hong Kong (HKUMed) has discovered how to impede invasive cell migrations by blocking the synthesis of PI(3,4)P2 lipids that are excessively produced in cancer cells. By the inhibition of PI(3,4)P2 synthesis, invasive cell migrations are effectively suppressed in various models, including in the triple-negative breast cancer cell line. This study has revealed a druggable target to suppress cancer metastasis, the malignant spread of cancer cells, which ranks highest in the cause of health-related mortality in Hong Kong1. The findings have been published in Proceedings of the National Academy of Sciences of the United States of America (PNAS).
Press Release: HKUMed researchers unveil a novel molecular mechanism underlying liver cancer drug resistance and tumour recurrence
Jun 01, 2021
Researchers at the LKS Faculty of Medicine, The University of Hong Kong (HKUMed) have uncovered a novel signalling pathway triggered by a protein called FUT1 to promote cancer stemness, contributing to drug resistance and tumour recurrence of liver cancer cells. The findings are now published in The Journal of Clinical Investigation (J Clin Invest).
Media Coverage: Dr Stephanie Ma shared in an interview on Topick
Apr 29, 2021
Dr Stephanie Ma shared her experience and the journey of study in an interview on Topick.
Press Release: HKUMed identifies Collagen IV differentially regulates planarian stem cell potency and lineage progression: Striving towards tissue regeneration in humans
Apr 26, 2021
A research team of LKS Faculty of Medicine, The University of Hong Kong (HKUMed) has identified a role of an extracellular matrix protein (ECM), Collagen IV, in the regulation of pluripotent stem cells in the regenerative flatworm (planarian). This collagen plays an important role in regulating how stem cells divide or change in the planarian, crucial to its regenerative capacity and can improve our understanding of human tissue regeneration. This study has been published in Proceedings of the National Academy of Sciences of the United States of America (PNAS).
Event: Croucher Science Week 2021
Mar 27 - Apr 11, 2021
Ms. Jane Loong and Mr. Matthew Wong, two PhD students of Dr Stephanie Ma' Lab, have participated in the Croucher Science Week 2021 via making two videos on "Who Stole My Snacks" and "A Day in the Life of a Biologist".
Press Release: HKUMed research team reveals a novel epigenetic mechanism in rRNA transcriptional regulation and raises new possibility of targeted therapy for cancer treatment
Mar 02, 2021
A research team at the School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong (HKUMed) identified a stable Spindlin1/C11orf84 protein complex preferentially recognises a non-canonical bivalent histone H3K4me3K9me3 mark and promotes rRNA transcription.
Media Coverage: Prof. Danny Chan's study picked on Biomedical Picture of the Day (BPoD)
Feb 21, 2021
Prof. Danny Chan's study on eLife was picked on Biomedical Picture of the Day (BPoD), MRC London Institute of Medical Sciences.
Media Coverage: Prof. DY Jin at the interview in TVB
Jan 23 - 24, 2021
Prof. DY Jin was interviewed by TVB to talk about COVID-19 and the vaccine.
Media Coverage: Dr Lai Kwok On's study featured at Croucher Science Week's Blog
Dec 28, 2020
A research team led by Dr Lai Kwok On (Croucher Fellowship 2003) at the University of Hong Kong has uncovered a previously uncharacterised function of the TBC1D24 gene in the maintenance of neuronal connections in the brain, a discovery that could eventually lead to new therapeutic pathways for patients suffering from epilepsy and intellectual disability.
Media Coverage: Dr Alan Wong at the interview in Sing Tao Daily
Dec 23, 2020