• Cancer evolution
• Population genetics
• Systems biology
• Statistical learning

As part of the unique group of scientists with a combination of expertise in both quantitative thinking and biological understanding, my research - bridging cancer genomics, evolutionary biology and mathematics with single-cell experiments - has advanced understanding in the somatic evolution of normal and precancerous human tissues. Combining expertise with the SMA lab, we now focus on developing a data-tested quantitative biological framework for the evolution of hepatocellular carcinoma to reveal cellular plasticity and hierarchy in the liver. 

1. Gladys Y. P. Poon, Aditi Vedi et al. Single-cell DNA sequencing reveals pervasive positive selection throughout preleukemic evolution. Cell Genomics (2024); accepted.
2. Gladys Y. P. Poon, Caroline J. Watson et al. Synonymous mutations reveal genome-wide levels of positive selection in healthy tissues. Nature Genetics 53, 1597–1605 (2021).
3. Watson, C.J., Papula, A.L., Gladys Y. P. Poon et al. The evolutionary dynamics and fitness landscape of clonal haematopoiesis. Science 367, 1449–1454 (2020).

• Bye-fellowship (2020-2021) at Magdalene College in recognition of research excellence.

We are actively recruiting postgraduate students and research assistants to join our lab. Please email Dr. Poon directly for potential projects.