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May 23, 2017

Seminar - Inflammatory Hypoxia - Mechanisms and Meaning of Cellular Oxygen Sensing (Speaker: Professor Dr. Joachim Fandrey)

Professor Dr. Joachim Fandrey
Professor of Physiology and Head
Institute of Physiology
University of Duisburg-Essen, Essen, Germany

Date: Tue, 23-May-2017
Time: 11:00 AM
Venue: Room A2-08, Mrs Chen Yang Foo Oi Telemedicine Centre 
2/F, William MW Mong Block, Faculty of Medicine Building 
21 Sassoon Road, Pokfulam, Hong Kong


The activation of hypoxia-inducible factor-1 (HIF-1) has been recognized as the key event in adaptation to hypoxia. HIF-1 complex assembly was studied by 2-photon-laser microscopy (2PLM) in living cells using fluorescence resonance energy transfer (FRET). Because HIF-1 gains increasing importance in hypoxia during inflammatory settings the role of HIF-1 activation in dendritic cells and macrophages was studied in vivo in a mouse model of inflammatory bowel disease. Here the pivotal role of HIF-1 activation in myeloid cells for connecting innate and adaptive immunity became evident.