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Aug 28, 2020

Lecture: Targeting the cyclin-dependent kinase 5 in metastatic melanoma (Professor Peter Sicinski)

Professor Peter Sicinski
Dana Farber Cancer Institute
Harvard Medical School, USA

Date: Friday, 28 August 2020

Venue: Zoom

Time: 9:00 a.m. - 10:15 a.m.

(Please register on or before 5pm of August 26, 2020.  Zoom link will be emailed to registrants after the close of registration)

The cyclin-dependent kinase 5 (CDK5), originally described as a neuronal-specific kinase, is also frequently activated in human cancers. Using conditional CDK5 knockout mice and a mouse model of highly metastatic melanoma, we found that CDK5 is dispensable for the growth of primary tumors. However, we observed that ablation of CDK5 completely abrogated the metastasis, revealing that CDK5 is essential for the metastatic spread. In mouse and human melanoma cells CDK5 promotes cell invasiveness by directly phosphorylating an intermediate filament protein, vimentin, thereby inhibiting assembly of vimentin filaments. Chemical inhibition of CDK5 blocks the metastatic spread of patient-derived melanomas in patient-derived xenograft (PDX) mouse models. Hence, inhibition of CDK5 might represent a very potent therapeutic strategy to impede the metastatic dissemination of malignant cells.