Date: Wednesday, 30 March 2022

Time: 5:00 p.m. - 6:00 p.m.

via Zoom: https://hku.zoom.us/meeting/register/tJUvcuyhrz0oGtKRqqeKugBi6KWyxakT2X52

Meeting ID: 912 5591 6206

Passcode: 558828

5:00 p.m.

Speaker: Dr. Qiannan TANG (Post-doctoral Fellow)
Primary Supervisor: Prof. Pengtao LIU
Presentation Title: Application of EPSC/EPSCM in immunology research
Abstract: Expanded potential stem cell (EPSC) is a novel stem cell type established by our lab previously, which possess developmental potency to all embryonic and extra-embryonic cell lineages. The culture condition for EPSC, termed as EPSC-medium (EPSCM), is comprised with 4 small molecular inhibitors, targeting Wnt-signaling and Scr pathway. EPSCM is capable to induce extended potential on other stem cell types. Here, we explored the possibility of utilizing EPSCM on culturing immune cell types with stemness, such as stem cell like memory T cells (TSCM). The preliminary data suggested that inhibitors from EPSCM increased the proportion of mouse TSCM in in vitro culture which could be potentially applied for the manufacture of CAR-T.

5:30 p.m. 

Speaker: Dr. Shuo HAN (Post-doctoral Fellow)
Primary Supervisor: Prof. Jiandong HUANG
Presentation Title: The long noncoding RNA NORAD regulates axonal transport
Abstract: ELong noncoding RNAs (lncRNAs) have recently emerged as biological cellular regulators in the neural system. However, it is not known whether a lncRNA coordinately regulates the intracellular trafficking of target mRNAs to sites of translation in remote axons and dendrites. Given the evidence suggestive of regulatory roles of lncRNAs in neuronal development, we found lncRNA NORAD may orchestrate the spatial gene expression of a newly identified RNA regulon that is essential for axonal viability by binding with SFPQ (splicing factor, poly-glutamine rich) and KLC1 (kinesin light chain 1). Suggesting NORAD might be a key molecule for neurogenesis.

ALL ARE WELCOME

Should you have any enquiries, please feel free to contact Miss Veronica Kwok at 3917 9515.