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Jan 17, 2017

Seminar - Single, Duo, and Flexible Aptamers for Biosensing and Biotechnological Application (Speaker: Professor Man Bock GU)

Professor Man Bock GU
Professor & Chair, Department of Biotechnology
Director, BK21 PLUS for Biotechnology
Korea University, Seoul, Republic of Korea

Date: Tuesday, 17-January-2017
Time: 4:30 p.m.
Venue: Room A2-08, Mrs Chen Yang Foo Oi Telemedicine Centre 
2/F, William MW Mong Block, Faculty of Medicine Building 
21 Sassoon Road, Pokfulam, Hong Kong


Aptamers are single-stranded nucleic acids with molecular recognition properties similar to antibodies, isolated by the in vitro selection and amplification process, SELEX. This talk will start with how aptamers are innovatively screened by using a new nano-material, graphene, without the immobilization of targets. A few successful examples using immobilization-free screening of aptamers will be presented, including a few aptamer duo cases, leading to a strip-type platform, which could be a reliable platform for commercialization eventually. In addition, some examples obtained from the interactions among aptamers, nanoparticles, and targets will be shown for single or flexible aptamers with successful implementation in aptasensors. Aptamer candidates are analyzed and heuristically engineered for developing the world's shortest octamer aptamer with highly enhanced affinity. Such sequence-based engineering of aptamers has resulted in ultrasensitive biosensing, especially for the detection of antibiotics.