School of Biomedical Sciences cordially invites you to join the following seminar:

Date: 15 April 2024 (Monday)
Time: 9:30 am – 10:30 am
Venue: Lecture Theatre 2, G/F, William M.W. Mong Block, 21 Sassoon Road

Speaker: Professor Tatyana Grinenko, Professor at Ruijin Hospital, affiliated with Shanghai Jiao Tong University
Talk Title: CD38 enzymatic activity promotes hematopoietic stem cell dormancy

Biography

Grinenko Tatyana is a professor at Ruijin Hospital, affiliated with Shanghai Jiao Tong University. She obtained an MD at Moscow State University, Russia, in 2002 and got a PhD in 2006 at the Blokhin’s Cancer Research Center, Moscow. From 2006-2008 she was a scientist at Engelhardt Institute of Molecular Biology of Russian Academy of Science, Moscow. In 2009, Tatyana moved to Germany and worked at the Center for Regenerative Therapies in Dresden. In 2015, she moved as a PI to the Technical University of Dresden, Germany. Her field of expertise is experimental hematology. She is investigating fate decisions of hematopoietic stem cells in steady-state conditions and in response to stress.

Abstract
A subpopulation of deeply quiescent, so-called dormant hematopoietic stem cells (dHSCs) resides at the top of the hematopoietic hierarchy and serves as a reserve pool for HSCs. The state of dormancy protects the them from exhaustion throughout life; however, excessive dormancy may prevent an efficient response to hematological stresses. However, the mechanisms maintaining HSC dormancy remain elusive. We identify CD38 as a novel surface marker for the isolation of murine dHSCs. We demonstrate that CD38 cyclase activity regulates the expression of the transcription factor c-Fos by increasing the release of Ca2+ from the endoplasmic reticulum. c-Fos induces the expression of the cell cycle inhibitor p57Kip2 to drive HSC dormancy. Moreover, we found that CD38 ecto-enzymatic activity at the neighboring CD38-positive cells promote human HSC quiescence. Pharmacological manipulations of this pathway can provide new strategies to improve the success of stem cell transplantation and blood regeneration after injury or disease.

ALL ARE WELCOME

Should you have any enquiries, please feel free to contact Miss Crystal Chan at 3917 6830.