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Nov 24, 2017

Seminar - Luminal progenitors in prostate regeneration and tumour initiation (Speaker: Dr. CHUA Chee Wai)

Dr. CHUA Chee Wai​
Principal Investigator 
Laboratory of Prostate Tumor Biology and Modeling
Renji-Med X Clinical Stem Cell Research Center
State Key Laboratory of Oncogenes and Related Genes
Department of Urology, Renji Hospital, School of Medicine
Shanghai Jiao Tong University, Shanghai, China

Date: Fri, 24-November-2017
Time: 4:00 PM
Venue: Seminar Room 4, G/F, Laboratory Block
Faculty of Medicine Building 
21 Sassoon Road, Pokfulam, Hong Kong

In the prostate, androgen receptor (AR) is a master regulator essential for development and tumourigenesis, but its specific functions in prostate stem/progenitor cells have not been elucidated. In this presentation, I will first talk about the investigation of AR function in CARNs (CAstration-Resistant Nkx3.1-expressing cells), a luminal stem/progenitor that functions in prostate regeneration and can serve as a cell of origin for prostate cancer. Secondly, I will describe the establishment of a novel three-dimensional culture system that allows the maintenance and propagation of luminal progenitors and cancer cells as organoids, and preserves intact androgen response and AR signalling.