Professor Philippa Francis-West
Group Leader, Centre for Craniofacial Biology and Regeneration
King’s College London, UK

Date: Thursday, 8-November-2018
Time: 5:00 p.m.
Venue: Seminar Room 1, G/F, Laboratory Block,
Faculty of Medicine Building,
21 Sassoon Road, Pokfulam, Hong Kong

Summary:
The aim of the research team is to understand the role of the Fat4-Dchs1 signalling pathway during mammalian development. This pathway is essential for human development as mutations in FAT4 and DCHS1 result in Van Maldergem’s syndrome characterized by a many developmental defects including altered craniofacial development. Fat4 and Dchs1 act together to coordinate cell polarity and growth via Yap/Taz, co-transcriptional effectors of the Hippo pathway. This seminar will describe the Fat4-Dchs1 pathway and show how Fat4-Dchs1 regulate both the size (cranial bones) and shape of bones (sternum).

ALL ARE WELCOME