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May 28, 2019

Seminar - Systems Genetics in Biomedical Discovery: From Novel Mechanisms to New Therapies for Cardiometabolic Diseases (Speaker: Professor Yibin Wang)

Professor Yibin Wang
Departments of Anesthesiology, Physiology and Medicine
David Geffen School of Medicine at UCLA, USA

Date: Tuesday, 28-May-2019
Time: 4:00 p.m.
Venue: Seminar Room 4, G/F, Laboratory Block
Faculty of Medicine Building
21 Sassoon Road, Pokfulam, Hong Kong

The pathogenesis of heart failure and metabolic disorder is highly heterogenous and complex, involving many genetic and environmental factors. These complexities post real challenge for us to establish disease mechanisms and to develop more effective and personalized therapies. In the past decade, Professor Wang’s team have developed a novel approach by integrating comprehensive phenotype and omics studies with systems analysis across a hybrid mouse diversity panel (HMDP) under well-defined pathological stressors. These studies leverage the power of genetics with unbiased omics based analysis to uncover novel genes and gene modules associated with specific clinical features of cardiometabolic diseases. In particular, they discovered several novel mechanisms contributing to the onset of cardiometabolic diseases, including RNA processing, long non-coding RNA mediated epigenetic modulation and branched-chain amino acid catabolism in the onset and progression of heart failure, diabetes and obesity. These findings highlight the power of genetics combined with systems approach in studying complex human diseases.