Professor CHEAH, Kathryn Song Eng 謝賞恩
- BSc (U of London); PhD (Cambridge)
- Jimmy and Emily Tang Professor in Molecular Genetics
- Chair of Biochemistry
- Understanding genes, their regulation and function with emphasis on development.
- The genetic and molecular basis of inherited and degenerative skeletal disorders.
The Mission of her group is to make significant contributions through multidisciplinary synergistic partnerships and cutting edge science. Her group aspires to reach the long term Vision of “Bench to Bedside” research, translating discovery to the clinic. Some key contributions of her group are:
- Sox2 as a master “hearing gene”;
- Molecular insights into the function of Sox9, the master gene for development of cartilage;
- Discovery of a mechanism that explains how mutations causing ER stress in chondrocytes, can affect their differentiation and cell death and thereby cause skeletal disorders;
- Showed that chondrocytes become osteoblasts during bone formation and repair, thereby resolving a century-long debate about this possibility.
Professor Kathryn Cheah is Chair Professor of Biochemistry at The University of Hong Kong. She received a BSc degree in Biology from the University of London, U.K. and a PhD from the University of Cambridge, U.K. in Molecular Biology. After postdoctoral research in the University of Manchester (UK) and the Imperial Cancer Research Fund, London, she joined the University of Hong Kong in 1983. She was Head of the Department of Biochemistry from 1997-2009 and Director of the Li Ka Shing Faculty of Medicine Centre for Reproduction, Development and Growth from 2004-2009. She is Convenor of the University’s Strategic Research Theme on Development & Reproduction.
The driving motivation of her research is the realisation that, with an ageing population worldwide, genomic and regenerative medicine will play critical roles in helping to preserve healthy growth and quality of life. The Mission of her group is to make significant contributions through multidisciplinary synergistic partnerships and cutting edge science to enable ambitious research questions to be tackled. By applying the new knowledge to the development of strategies for the reconstitution or repair of tissues, her group aspires to reach the long term Vision of “Bench to Bedside” research, translating discovery to the clinic.
She is Director of a multidisciplinary collaborative group involving scientists and clinicians aiming to identify genetic factors that contribute to the risk of degenerative intervertebral disc disease (IDD), which is a common cause of lower back pain and disability. The group recently identified a new genetic risk factor for lumbar disc degeneration. These findings will contribute to a better prediction of total personal risk for IDD that will improve prevention and disease management.
She was awarded a Croucher Foundation Senior Fellowship in 2000 and was elected Fellow of The World Academy of Sciences (TWAS) in 2013. She was the founding President of the Hong Kong Society for Developmental Biology (HKSDB) serving from 2004 to 2013 during which time she represented Hong Kong in the Asia-Pacific Developmental Biology Network (APDBN) and the International Society of Developmental Biology. She was the President of the International Society for Matrix Biology 2006-2008. In 2012 she was elected to the Board of Directors of the International Society of Differentiation.
She was Co-Vice-Chair and Co-Chair for the Gordon Research Conferences (GRC) on Cartilage Biology and Pathology in 2009 and 2011 respectively. In 2012 she was appointed to the GRC Advisory Board for Hong Kong. She has organised several Croucher Foundation Advanced Study Institutes on Genetics and on Stem Cells and actively promotes public understanding of science.
- Postdoc Fellow in Stem Cells and Regenerative Medicine
- Z. Tan, M. Kong, S. Wen, K.Y. Tsang, B. Niu, C. Hartmann, D. Chan, C.C. Hui, K.S.E. Cheah¥ (2020) IRX3 and IRX5 Inhibit Adipogenic Differentiation of Hypertrophic Chondrocytes and Promote Osteogenesis. J Bone Miner Res. doi: 10.1002/jbmr.4132.
International Bone Marrow Adiposity Society ‘Paper of the Month’ (http://bma-society.org/paper-of-the-month/).
- Y. Zhang, Z. Zhang, P. Chen, C.Y. Ma, C. Li, T.K.Y. Au, V. Tam, Y. Peng, R. Wu, K.M.C. Cheung, P.C. Sham, H.F. Tse, D. Chan, V.Y. Leung, K.S.E. Cheah¥ and Q. Lian¥ (2020) Directed Differentiation of Notochord-like and Nucleus Pulposus-like Cells Using Human Pluripotent Stem Cells. Cell Reports 30(8):2791-2806.e5. doi: 10.1016/j.celrep.2020.01.100. PMID: 32101752. (¥ Co-corresponding)
- K.Y. Tsang and K.S.E. Cheah¥ (2019) The extended chondrocyte lineage: implications for skeletal homeostasis and disorders. Current Opinion in Cell Biology 61: 132-140. doi: 10.1016/j.ceb.2019.07.011.
- M. Wang*, Z. Tan*, B. Niu, K.Y. Tsang, A. Tai, W.C.W. Chan, R.L.K. Lo, K.K.H. Leung, N.W.F. Dung, N. Itoh, M.Q. Zhang, D. Chan and K.S.E. Cheah¥ (2018) Inhibiting the Integrated Stress Response Prevents Aberrant Chondrocyte Differentiation and Alleviates Skeletal Defects in Chondrodysplasia. eLife, e37673. doi: 10.7554/eLife.37673.
- Z. Tan*, B. Niu*, K.Y. Tsang, I.G. Melhado, S. Ohba, X. He, Y. Huang, C. Wang, A.P. McMahon, R. Jauch, D. Chan, M.Q. Zhang and K.S.E. Cheah¥ (2018) Synergistic co-regulation and competition by a SOX9-GLI-FOXA phasic transcriptional network coordinate chondrocyte differentiation transitions. PLoS Genetics 14(4):e1007346. doi: 10.1371/journal.pgen.1007346. [Link to Growth Plate Differential Gene Expression Library (GP-DGEL)]
- A. Tai, M. Cheung, Y-H Huang, R. Jauch, M.E. Bronner and K.S.E. Cheah¥ (2016) SOXE neofunctionalization and elaboration of the neural crest during chordate evolution. Scientific Reports 13:6:34964. doi: 10.1038/srep34964.
- K.Y. Tsang, D. Chan and K.S.E. Cheah¥ (2015) Fate of growth plate hypertrophic chondrocytes: Death or lineage extension? Development, Growth & Differentiation 57: 179-192.
- L. Yang, K.Y. Tsang, H.C. Tang, D. Chan and K.S.E. Cheah¥ (2014) Hypertrophic chondrocytes can become osteoblasts and osteocytes in endochondral bone formation. Proc Natl Acad Sci USA. 111(33): 12097-12102.
- C.W. Cheng, B. Niu, M. Warren, L.H. Pevny, R. Lovell-Badge, T. Hwa¥ and K.S.E. Cheah¥ (2014) Predicting the spatiotemporal dynamics of hair follicle patterns in the developing mouse. Proc Natl Acad Sci USA. 111(7): 2596-2601.
- J.A.J. Liu, M.H. Wu, C.H. Yan, B.K.H. Chau, H. So, A. Ng, A. Chan, K.S.E. Cheah, J. Briscoe and M. Cheung (2013) Phosphorylation of Sox9 is required for neural crest delamination and is regulated downstream of BMP and canonical Wnt signaling. Proc Natl Acad Sci USA. 110(8): 2882-2887.
- V.Y.L. Leung, B. Gao, K.K.H. Leung, I.G. Melhado, S.L. Wynn, T.Y.K. Au, N.W.F. Dung, J.Y.B. Lau, A.C.Y. Mak, D. Chan and K.S.E. Cheah¥ (2011) Sox9 governs differentiation stage-specific gene expression in growth plate chondrocytes via direct concomitant transactivation and repression. PLoS Genetics 7(11): e1002356.
- A.W.L. Leung, S.Y.Y. Wong, D. Chan, P.P.L. Tam¥ and K.S.E. Cheah¥ (2010) Loss of procollagen IIA from the anterior mesendoderm disrupts the development of mouse embryonic forebrain. Developmental Dynamics 239: 2319-2329.
- A.C. Mak, I.Y.Y. Szeto, B. Fritzsch and K.S.E. Cheah¥ (2009) Differential and overlapping expression pattern of Sox2 and Sox9 in inner ear development. Gene Expression Patterns 9(6): 444-453.
- K.Y. Tsang*, D. Chan*, D. Cheslett, W.C.W. Chan, C.L. So, I.G. Melhado, T.W.Y. Chan, K.M. Kwan, E.B. Hunziker, Y. Yamada, J.F. Bateman, K.M.C. Cheung and K.S.E. Cheah¥ (2007) Surviving ER Stress Is Coupled to Altered Chondrocyte Differentiation and Function. PLoS Biology 5(3): e44.
- A.E. Kiernan*, A.L. Pelling*, K.K.H. Leung, A.S.P. Tang, D.M. Bell, C. Tease, R. Lovell-Badge, K.P. Steel and K.S.E. Cheah¥ (2005) Sox2 is required for sensory organ development in the mammalian inner ear. Nature 434: 1031-1035.
(* equal contribution; ¥ corresponding author)
- K.S.E Cheah & K.M.C. Cheung (2002). Uses of a transgenic mouse containing a type X collagen mutant. US Patent no. 6,369,295
- K.S.E Cheah & K.M.C. Cheung (2005). Uses of a transgenic animals containing a type X collagen mutant. European Patent no. 1,159,423, German part no. 69924158.8.
- Interview in TVB news health programme《醫療室》(2018-12-03): 港大成功研究抑制細胞變異 冀研發侏儒症藥物
- Press release (2018-10-8): HKU Scientists Discover a Potential Therapeutic Strategy to Prevent Dwarfism Caused by Excessive Cellular Stress
- 新聞稿 (2018-10-8): 港大發現因細胞應激過度活躍而引起的侏儒症的醫治方向
- Apple Daily (2018-10-22): 助兒童骨骼正常生長 無副作用 港大研新法 抑制侏儒症
- Apple Daily (2018-10-22): 藥物進一步研究或可兼治糖尿關節炎
- HKO1 (2018-10-22): 港大治療侏儒症藥物研究有突破-小鼠注射一個月-骨骼增長一成
- Oriental Daily (2018-10-22): Dr.東：抑制劑奏效 港大研治侏儒症現曙光
- Hong Kong Economic Journal (2018-10-22): MCDS侏儒症有藥醫
- Press release (2014-8-6): HKU researchers resolve century-long debate about how bone cells develop
- 新聞稿 (2014-8-6): 香港大學學者破解骨細胞發育的世紀之謎
- International Innovation - ResearchMedia
- Interview by SCMP
- UGC Areas of Excellence Scheme
- RGC Theme-based Research Scheme
- 2015–2020: Genetics and Functional Genomics of Neural Crest Stem Cells and Associated Disease: Hirschsprung Disease (Co-PI, Project coordinator: Prof. Paul Tam)
- 2013–2018: Functional analyses of how genomic variation affects personal risk for degenerative skeletal disorders (Project coordinator)
- Project Presentation in Theme-based Research Scheme Public Symposium, 9 December 2017 (from
Research Grants Council, Hong Kong):
- Project Presentation in Theme-based Research Scheme Public Symposium, 9 December 2017 (from
- RGC Collaborative Research Fund (CRF)
- 2020–2023: Functional and systems analyses of regulatory networks controlling cell fate and lineage development of intervertebral disc cells (Project coordinator and co-PI)
- 2017–2020: Multi-scale single-cell optical imaging: architecture and biomedical applications. (Co-PI, Projector coordinator: Dr. Kevin Tsia)
- RGC General Research Fund (GRF) Projects
- 2019–2022: Analyses of progenitors and differentiation trajectories in the nucleus pulposus and their relevance in intervertebral disc degeneration
- 2017–2020: Molecular control of hypertrophic chondrocyte cell fate and lineage extension
- 2014–2017: Mechanisms controlling determination of sensory versus non-sensory fate in inner ear development
- 2013–2016: Mechanistic insights into the genesis and physiological role of hypertrophic chondrocyte-derived osteoblasts
- 2012–2015: Genetic analyses of the roles of Sox2 and Sox18 in hair follicle development
- 2010–2014: Genetic analyses of sensory fate determination in inner ear development
- NSFC/RGC Joint Research Project
- 2013–2017: Identifying critical transitions and gene regulatory networks controlling phases of chondrocyte differentiation in the growth plate
- Health and Medical Research Fund (HMRF)
- 2020–2023: Mechanism of MMP14 control of bone mass via chondrocyte to osteoblast conversion
- 2019–2022: Role(s) of TAGLN expressing cells in intervertebral disc development, homeostasis and degeneration
- 2018–2020: Identification of Sox2 otic enhancers and their utility for restoring hearing and vestibular function
- 2017–2020: Sox9 control of neuromesodermal progenitors
- 1997: Honorary Professor at Peking Union Medical College, Beijing China
- 2000: Croucher Foundation Senior Fellowship of HK and the HKU Outstanding Researcher award.
- 2011-2012: Senior External Fellow of the University of Freiberg Institute of Advanced Studies, Germany.
- 2013: Elected Fellow of The World Academy of Science (TWAS).
- Advisory Board: J. Biomedical Science, 1999–
- Editorial Board: Nature Scientific Reports, 2011–
- Editorial Board: Genesis, 2000–
- Editorial Board: Development Growth & Differentiation (DGD), 2006–
- Editorial Review Board: Journal of Orthopedic Research, 2019–2021
- Senior Editor: eLife, June 2019–
- Editorial Advisor: Emerging Topics in Life Sciences, 2019–2023
Last update: 2020-08-24