• Curriculum development in Biotechnology Entrepreneurship
• Development of state-of-the-art biosensing technologies for the detection and diagnosis of diseases in human and animals
• Novel drug target identification and structure-based drug design against infectious agents

• Head of Research, Ilumi Health Limited, Hong Kong Science Park, Hong Kong
• Research Assistant Professor, School of Life Sciences, The Chinese University of Hong Kong, Hong Kong
• Research Assistant Professor, Department of Physiology, University of Hong Kong, Hong Kong
• Senior Research Fellow, Nanyang Technological University, Singapore
• Postdoctoral Scientist, University of Oxford, United Kingdom
• Postdoctoral Fellow, Department of Biochemistry, University of Hong Kong
• Ph.D., Department of Biochemistry, The Chinese University of Hong Kong, Hong Kong
• B. Sc. Hons, Department of Biochemistry, The Chinese University of Hong Kong, Hong Kong

1. Ting KY, Leung CF, Graeff RM, Lee HC, Hao Q, Kotaka M*. (2016). Porcine CD38 exhibits prominent secondary NAD(+) cyclase activity. Protein Sci. 25:650-61.
2. Cheung YW, Kwok J, Law AWL, Watt RM, Kotaka M*, & Tanner JA*. (2013). Structural basis for discriminatory recognition of Plasmodium lactate dehydrogenase by a DNA aptamer. Proc. Natl. Acad. Sci. USA. 110:15967-15972. (Co-corresponding authorship).
3. Wang Y, Dutta S, Karlberg H, Devignot S, Weber F, Hao Q, Tan YJ, Mirazimi A, Kotaka M*. (2012). Structure of Crimean-Congo haemorrhagic fever virus nucleoprotein: Superhelical homo-oligomers and the role of caspase-3 cleavage. J. Virol. 86:12294-12303.
4. Chen MW^, Kotaka M^, Vonrhein C, Bricogne G, Rao F, Chuah ML, Svergun D, Schneider G, Liang ZX, Lescar J. (2012). Structural insights into the regulatory mechanism of the response regulator RocR from Pseudomonas aeroginosa in cyclic di-GMP signalling. J. Bacteriol. 194:4837-46. (^Co-first authorship).
5. Kotaka M, Graeff R, Zhang L, Lee HC, Hao Q. (2012). Structural studies of intermediates along the cyclisation pathway of Aplysia ADP-ribosyl cyclase. J. Mol Biol. 415:514-526.
6. Kotaka M, Kong R, Qureshi I, Ho QS, Sun H, Liew CW, Goh LP, Cheung P, Mu Y, Lescar J, Liang ZX. (2009). Structure and catalytic mechanism of the thioesterase CalE7 in enediyne biosynthesis. J. Biol Chem. 284:15739-49.
7. Kotaka M, Johnson C, Lamb H, Hawkins AR, Ren J, and Stammers DK. (2008). Structural analysis of the recognition of the negative regulator NmrA & DNA by the zinc finger from the GATA-type transcription factor AreA. J. Mol Biol. 381:373-82. (Selected for Faculty of 1000 Biology).

As PI:

• RGC/GRF. 2013-2014.
• RGC/GRF. 2012-2014.
• RGC/GRF. 2010-2012.

As Co-I:

• RGC/GRF. 2011-2013.