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Academic Staff

Professor LIU, Yang 劉揚

Professor LIU, Yang 劉揚

  • BSc, MSc (Sun Yat-sen U), PhD (U of Guelph)
  • Assistant Professor
L3-78, Laboratory Block, 21 Sassoon Road, Hong Kong
+852 3917 9792
+852 2855 1254

How epigenetic markers on chromatin are regulated by histone chaperones and chromatin remodelers

Dr. LIU Yang is currently an Assistant Professor in the School of Biomedical Sciences at the University of Hong Kong. Yang received her BSc and MSc degree in Sun-Yat sen University, China and PhD degree in the University of Guelph, Canada. Yang then worked as a postdoc research fellow in chromatin biology in the University of Colorado at Boulder, USA. Yang joined the University of Hong Kong as an Assistant Professor in 2022.

The organization of genomic DNA into defined nucleosomes is considered as a universal and ancestral feature of the eukaryotes, which profoundly affect all DNA-related processes. LIU lab research explores the epigenetic regulations, which aims at understanding how epigenetic variations are incorporated and maintained in the genome, how epigenetic markers on histones are regulated by histone chaperones and chromatin remodelers, and how chaperones/remodelers and histone PTMs/variants interplay in diseases such as cancer.

* Co-first author

  1. Liu, Y., Bisio, H., Toner, C.M., Jeudy, S., Philippe, N., Zhou, K., Bowerman, S., White, A., Edwards, G., Abergel, C. and Luger, K. Virus-encoded histone doublets are essential and form nucleosome-like structures. Cell. 2021 August 5; 184(16):4237-4250.
  2. Liu, Y.*; Zhou, K.*; Zhang, N.; Wei, H.; Tan, Y.Z.; Zhang, Z.; Carragher, B.; Potter, C.S.; D'Arcy, S. and Luger, K. FACT caught in the act of manipulating the nucleosome. Nature. 2020 Jan 16; 577(7790):426-431.
  3. Zhou, K., Liu, Y. and Luger, K. Histone chaperone FACT FAcilitates Chromatin Transcription: mechanistic and structural insights. Current Opinion in Structural Biology. 2020; 65:26-32.
  4. Wang, T.*, Liu, Y.*, Edwards, G., Krzizike, D., Scherman, H. and Luger, K. The histone chaperone FACT modulates nucleosome structure by tethering its components. Life Science Alliance. 2018 Aug; 1(4): e201800107.
  5. Mattiroli, F., Gu, Y., Yadav, T., Balsbaugh, J.L., Harris, M.R., Findlay, E.S., Liu, Y., Radebaugh, C.A., Stargell, L.A., Ahn, N.G., Whitehouse, I., Luger, K. DNA-mediated association of two histone-bound complexes of yeast Chromatin Assembly Factor-1 (CAF-1) drives tetrasome assembly in the wake of DNA replication. eLife. 2017 Mar 18; 6: e22799.
  6. Liu, Y., de Jong, J., Nagy, E., Theilmann, D.A., and Krell, P.J. Nuclear translocation sequence and regions in AcMNPV ME53 important for optimal baculovirus production. Journal of Virology. 2016 Mar 28; 90(8):3953-65.