• Molecular virology
• Innate immune sensing of virus and viral pathogenesis
• Recombinant virus technology and virus engineering

• BSc, PhD (HKU)

My main research focus is to understand the molecular basis of viral-host interaction that determines basic viral life cycle, disease pathogenesis and virus evolution and adaptation to a specific host. Through the techniques of molecular biology, cell biology and virus engineering, our team aims at acquiring basic evidences to the research focus. Not only do we hope to develop new knowledge to the field of molecular virology, in collaboration with scientists in HKU or outside HKU, we also hope to establish prototypes and platforms that can facilitate the development of vaccines, therapeutics, antivirals, novel recombinant virus vectors and engineered viruses in preventing and treating viral and non-viral diseases.

1. Cheung, P. H. H., Ye, Z. W., Lui, W.Y., Ong, C.P., Chan, P., Lee, T. T., Tang, T. T., Yuen, T. L., Fung, S. Y., Cheng, Y., Chan, C.P., Chan, C.P., Jin, D.Y (2022). Production of single-cycle infectious SARS-CoV-2 through a trans-complemented replicon. J Med Virol. 2022 Aug 8.
2. Cheung, P. H. H., Chan, C. P., Jin, D. Y (2022). Lessons learned from the fifth wave of COVID-19 in Hong Kong in early 2022. Emerg Microbes Infect. 2022 Dec;11(1):1072-1078.
3. Ong CP, Tang K, Cheung P.H. H., Zhang H, Tang TT, Xue Y, Wang J, To KK, Yuan S, Ye ZW, Jin DY. Monovalent vaccination with inactivated SARS-CoV-2 BA.5 protects hamsters against Omicron but not non-Omicron variants. NPJ Vaccines. 2023 Nov 20;8(1):177.
4. Cheung, P. H. H., Lee, T. T., Kew, C., Chen, H., Yuen, K. Y., Chan, C. P., & Jin, D. Y. (2020). Virus subtype-specific suppression of MAVS aggregation and activation by PB1-F2 protein of influenza A (H7N9) virus. PLoS Pathogens, 16(6), e1008611.
5. Cheung, P. H. H., Ye, Z. W., Lee, T. T., Chen, H., Chan, C. P., & Jin, D. Y. (2020). PB1-F2 protein of highly pathogenic influenza A (H7N9) virus selectively suppresses RNA-induced NLRP3 inflammasome activation through inhibition of MAVS-NLRP3 interaction. Journal of Leukocyte Biology, 10.1002/JLB. 4AB0420-694R.
6. Cheung, P. H. H., Lee, T. T., Chan, C. P., & Jin, D. Y. (2020). Influenza A virus PB1-F2 protein: An ambivalent innate immune modulator and virulence factor. Journal of Leukocyte Biology, 107(5), 763–771.
7. Chan, C. P., Yuen, C. K., Cheung, P. H. H., Fung, S. Y., Lui, P. Y., Chen, H., Kok, K. H., & Jin, D. Y. (2018). Antiviral activity of double-stranded RNA-binding protein PACT against influenza A virus mediated via suppression of viral RNA polymerase. FASEB Journal, 32(8), 4380–4393.
8. Cheung, P. H. H., Chan, C. P., & Jin, D. Y. (2017). To announce or not to announce: What is known about the 2016–2017 influenza season in Hong Kong? Emerging Microbes & Infections, 6(9), e78.

Health and Medical Research Fund (HMRF), 2022 (Co-Applicant)
Health and Medical Research Fund (HMRF), 2021 (Principal Applicant)
Health and Medical Research Fund (HMRF), 2019 (Principal Applicant)

• Associate member of American Society for Virology
• Travel Award for 42^nd Annual Meeting for American Society for Virology (2023)
• Travel Award for 37^th Annual Meeting for American Society for Virology (2018)
• Travel Award for 35^th Annual Meeting for American Society for Virology (2016)