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Research Postgraduate Programme

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Research Areas:

Staff

 

Brain and Cognitive Sciences

Cognitive functions are orchestrated by neurons and glial cells in different regions of the brain, and represent one of the major issues in neurodegenerative diseases and brain disorders. Our School collaboratively investigates the molecular events that support cognitive functions, including the formation and retraction of synapses, dendrites and axons. We use zebrafish, Xenopus, rat, and mouse as genetic model organisms to investigate neurodevelopment, neuromuscular junction formation, physiological functions of neurons and glial cells, neuroinflammation, and pathological mechanisms that lead to neurodegeneration and neurocognitive disorders. We also assess the value of deep brain stimulation, neuroprotective effects from exercise and diet, and the potential utility of stem cells in neuroregeneration. 

CFND

 

Contact Persons

Dr RCC Chang

Research interest: Neurodegeneration; Neuroimmunology; Alzheimer’s disease; Parkinson’s disease dementia; Microglia; Neuroprotection; Post-operative cognitive dysfunctions

Website: https://www.sbms.hku.hk/staff/raymond-chuen-chung-chang

 

Dr MCH Cheung

Research interest: Neural development; Modelling neurological diseases and melanoma

Website: https://www.sbms.hku.hk/staff/martin-chi-hang-cheung

 

Dr ML Fung

Research interest: Hypoxia physiology

Website: https://www.sbms.hku.hk/staff/man-lung-fung

 

Dr R Hervas Millan

Research interest: Functional protein aggregation; Functional amyloids; Electron-cryo microscopy; Memory persistence; Cellular memory

Website: https://www.sbms.hku.hk/staff/ruben-hervas-millan

 

Professor JD Huang

Research interest: Synthetic biology; Vaccines for infectious diseases and cancers; Biological pattern formation

Website: https://www.sbms.hku.hk/staff/jiandong-huang

 

Professor MSY Huen

Research interest: DNA repair; Genome stability; DNA damage responses; Cell cycle checkpoint control

Website: https://www.sbms.hku.hk/staff/michael-shing-yan-huen

 

Dr R Jauch

Research interest: Protein design and stem cell engineering; Directed molecular evolution in mammalian cells

Website: https://www.sbms.hku.hk/staff/ralf-jauch

 

Dr CSW Lai

Research interest: Two-photon in vivo imaging; Learning and memory; Synaptic plasticity; Cognitive neuroscience; Psychiatric diseases

Website: https://www.sbms.hku.hk/staff/cora-sau-wan-lai

 

Dr CW Lee

Research interest: Cellular, molecular, and developmental neurobiology; Muscle physiology and pathophysiology

Website: https://www.sbms.hku.hk/staff/chi-wai-lee

 

Dr LW Lim

Research interest: Behavioural, cellular and molecular neuroscience; Neuromodulation in psychiatric and neurodegenerative disorders

Website: https://www.sbms.hku.hk/staff/lee-wei-lim

 

Dr YQ Song

Research interest: Human genetics; Bioinformatics and functional genomics; Alzheimer’s disease

Website: https://www.sbms.hku.hk/staff/you-qiang-song

 

 

Cell Signalling and Cancer Biology

Cell signalling defines the means via which cells sense and respond to internal and external cues, and is fundamental to cell proliferation and survival, cell-cell communication, and cell differentiation and organismal development. For instance, when cells detect changes in nutrient levels within its microenvironment, a cascade of signalling events would ensue such that cell and tissue homeostasis can be maintained. One important focus of study within our School is cell signalling and how its alteration can lead to diseases including cancer. Members of our School are also researching on a wide variety of aspects of biology implicated in the origin and growth of cancer, including cancer stem cell and self-renewal, DNA replication and repair, metabolism, metastasis, cell cycle and immune escape. 

DNALib

Contact Persons

Dr CP Chan

Research interest: Molecular virology and innate immunity; Molecular biology and transcriptional regulation

Website: https://www.sbms.hku.hk/staff/chi-ping-chan

 

Dr LWT Cheung

Research interest: Cancer driver mutations; Cancer signalling; Drug sensitivity and resistance mechanisms

Website: https://www.sbms.hku.hk/staff/lydia-wai-ting-cheung

 

Dr MCH Cheung

Research interest: Neural development; Modelling neurological diseases and melanoma

Website: https://www.sbms.hku.hk/staff/martin-chi-hang-cheung

 

Dr YP Ching

Research interest: Centrosome biogenesis; Rho signalling; Chromosome instability and cancer metastasis

Website: https://www.sbms.hku.hk/staff/yick-pang-ching

 

Dr CYS Chung

Research interest: Chemical biology; Proteomics; Mass spectrometry; Molecular imaging; Medicinal chemistry

Website: https://www.sbms.hku.hk/staff/yik-sham-clive-chung

 

Dr ML Fung

Research interest: Hypoxia physiology

Website: https://www.sbms.hku.hk/staff/man-lung-fung

 

Dr B Gao

Research interest: Cell signalling in development and disease; Genetic and molecular basis of skeletal disorders

Website: https://www.sbms.hku.hk/staff/bo-gao

 

Dr M He

Research interest: Tissue development and regeneration; Mouse genetics and human organoids for disease modelling

Website: https://www.sbms.hku.hk/staff/mu-he

 

Professor MSY Huen

Research interest: DNA repair; Genome stability; DNA damage responses; Cell cycle checkpoint control

Website: https://www.sbms.hku.hk/staff/michael-shing-yan-huen

 

Dr A Javed

Research interest: Multi-omics analysis of cancers and rare diseases; Computational biology

Website: https://www.sbms.hku.hk/staff/asif-javed

 

Professor DY Jin

Research interest: Molecular virology; Innate antiviral response; Viral oncogenesis

Website: https://www.sbms.hku.hk/staff/dong-yan-jin

 

Dr SC Kwon

Research interest: RNA biology and genome engineering

Website: http://www.sbms.hku.hk/staff/sung-chul-kwon

 

Professor PT Liu

Research interest: Stem cells; Genetics and genomics; Developmental Biology; Hematopoiesis and immune cell functions; Cancer cell killers; Cell-based therapies

Website: https://www.sbms.hku.hk/staff/pengtao-liu

 

Dr SKY Ma

Research interest: Cancer stem cells; Tumour microenvironment; Drug resistance; Targeted therapy; Liver cancer; Basic/translational cancer research

Website: https://www.sbms.hku.hk/staff/stephanie-kwai-yee-ma

 

Dr CM Qian

Research interest: Epigenetic​s and genome instability; Structural biology

Website: https://www.sbms.hku.hk/staff/qian-chengmin

 

Dr RR Sugimura

Research interest: Organoids & Stem Cells; Cell Engineering; Immunology; Cancer Immunotherapy

Website: https://www.sbms.hku.hk/staff/rio-ryohichi-sugimura

 

Dr CM Tong

Research interest: Cancer targeted therapy; Therapy resistance and cancer stemness

Website: https://www.sbms.hku.hk/staff/man-carol-tong

 

Dr ASL Wong

Research interest: Genome editing; Protein engineering; Synthetic biology; Combinatorial genetics; Drug target discovery; Disease biology

Website: https://www.sbms.hku.hk/staff/alan-siu-lun-wong

 

Dr JWH Wong

Research interest: Cancer genomics; Proteomics and bioinformatics

Website: https://www.sbms.hku.hk/staff/jason-wing-hon-wong

 

Dr CH Yu

Research interest: Cell adhesion and cytoskeleton regulation; Podosome and invadopodium; Mechanobiology; Phosphatidylinositol signalling; Fluorescence microscopy

Website: https://www.sbms.hku.hk/staff/cheng-han-yu

 

Professor ZJ Zhou

Research interest: Chromatin architectural alterations in stem cell differentiation; Aging and development

Website: https://www.sbms.hku.hk/staff/zhongjun-zhou

CSCB

 

Genomics and Biomedical Data Sciences

Technological advances in genomics, proteomics, metabolomics, imaging, and access to a wide variety of digital health data in electronic health records, require a big data approach to scientific discovery and digital health innovation. Our School has expertise in developing and applying state-of-the-art statistical and computational methods to harness these big data to address a variety of biomedical problems. Key research areas include discovery of mutational signatures in cancer genomes, discovery of rare stem cell populations in cancers using single cell transcriptomic data, identification of causal mutations and the developmental origin of rare diseases, discovery of how altered gut microbiome can impact health, the use of metabolomics and proteomics technologies to identify novel disease biomarkers, and use of wearable devices, smartphones and artificial intelligence in modern digital healthcare. 

Genomics

 

Contact Persons

Professor D Chan

Research interest: Skeletal and matrix biology; Animal models of diseases; Stem cells and regeneration

Website: https://www.sbms.hku.hk/staff/danny-chan

 

Dr JWK Ho

Research interest: Bioinformatics; Artificial intelligence; Medical big data; Digital health technology; Metagenomics; Single cell genomics

Website: https://www.sbms.hku.hk/staff/joshua-wing-kei-ho

 

Dr YH Huang

Research interest: Bioinformatics; Machine learning; Statistical modelling; Single-cell genomics; Somatic mutations

Website: https://www.sbms.hku.hk/staff/yuanhua-huang

 

Dr A Javed

Research interest: Multi-omics analysis of cancers and rare diseases; Computational biology

Website: https://www.sbms.hku.hk/staff/asif-javed

 

Professor PT Liu

Research interest: Stem cells; Genetics and genomics; Developmental Biology; Hematopoiesis and immune cell functions; Cancer cell killers; Cell-based therapies

Website: https://www.sbms.hku.hk/staff/pengtao-liu

 

Dr YQ Song

Research interest: Human genetics; Bioinformatics and functional genomics; Alzheimer’s disease

Website: https://www.sbms.hku.hk/staff/you-qiang-song

 

Professor R Sun

Research interest: Advance virology and immunology by integrating genomic, proteomic, structural, quantitative, and deep learning approaches

Website: https://www.sbms.hku.hk/staff/sun-ren

 

Dr JWH Wong

Research interest: Cancer genomics; Proteomics and bioinformatics

Website: https://www.sbms.hku.hk/staff/jason-wing-hon-wong

BDS

 

Stem Cell, Molecular and Developmental Genetics

Research in developmental biology provides invaluable insights into the molecular events that underlie the diverse cellular changes as tissues and organs are formed during embryogenesis. However, as tissues and organs are formed from a single totipotent stem cell, namely the fertilized zygote, that undergoes well-defined cell divisions and progressive lineage differentiation to specific cell types in the body, it is tightly linked to stem cell biology. Further, it also links to the study of rare diseases where mutations in specific genes can result in developmental defects. Thus, this research area of the School in stem cell biology, developmental biology and functional genetics work hand in hand to resolve complex questions in understanding disease mechanisms, control of stem cell differentiation and cell function, with the opportunity to provide therapeutic interventions through drug discoveries and application of regenerative medicine. Specific areas of focus include musculoskeletal, neurological, metabolic, and ageing defects. 

Cell1  cell2

 

Contact Persons

Professor D Chan

Research interest: Skeletal and matrix biology; Animal models of diseases; Stem cells and regeneration

Website: https://www.sbms.hku.hk/staff/danny-chan

 

Dr MCH Cheung

Research interest: Neural development; Modelling neurological diseases and melanoma

Website: https://www.sbms.hku.hk/staff/martin-chi-hang-cheung

 

Dr B Gao

Research interest: Cell signalling in development and disease; Genetic and molecular basis of skeletal disorders

Website: https://www.sbms.hku.hk/staff/bo-gao

 

Dr M He

Research interest: Tissue development and regeneration; Mouse genetics and human organoids for disease modelling

Website: https://www.sbms.hku.hk/staff/mu-he

 

Professor JD Huang

Research interest: Synthetic biology; Vaccines for infectious diseases and cancers; Biological pattern formation

Website: https://www.sbms.hku.hk/staff/jiandong-huang

 

Dr R Jauch

Research interest: Protein design and stem cell engineering; Directed molecular evolution in mammalian cells

Website: https://www.sbms.hku.hk/staff/ralf-jauch

 

Dr CW Lee

Research interest: Cellular, molecular, and developmental neurobiology; Muscle physiology and pathophysiology

Website: https://www.sbms.hku.hk/staff/chi-wai-lee

 

Dr HGS Ling

Research interest: Metabolic reprogramming of T cells in chronic inflammatory diseases

Website: https://www.sbms.hku.hk/staff/gsling

 

Professor PT Liu

Research interest: Stem cells; Genetics and genomics; Developmental Biology; Hematopoiesis and immune cell functions; Cancer cell killers; Cell-based therapies

Website: https://www.sbms.hku.hk/staff/pengtao-liu

 

Dr YQ Song

Research interest: Human genetics; Bioinformatics and functional genomics; Alzheimer’s disease

Website: https://www.sbms.hku.hk/staff/you-qiang-song

 

Dr RR Sugimura

Research interest: Organoids & Stem Cells; Cell Engineering; Immunology; Cancer Immunotherapy

Website: https://www.sbms.hku.hk/staff/rio-ryohichi-sugimura

 

Professor ZJ Zhou

Research interest: Chromatin architectural alterations in stem cell differentiation; Aging and development

Website: https://www.sbms.hku.hk/staff/zhongjun-zhou

 

Structural, Chemical and Synthetic Biology

A transdisciplinary understanding of biomolecule function at the atomic level provides insights into the molecular biology underlying all of life and medicine. We are now moving from observations of the structure and dynamics of molecular complexes and machines (structural biology), towards perturbing these systems (chemical biology), through to re-engineering biomolecules by both rational design and evolution (synthetic biology). Our School has deep expertise in these areas - integrating structural biology with functional proteomics, nucleic acid evolution with translational technology, and artificial biological circuits with genome engineering. Such approaches are unveiling new ways to better understand biology and medicine, and allow translational angles across therapeutics, diagnostics and bioengineering. 

SCYB

Contact Persons

Dr CYS Chung

Research interest: Chemical biology; Proteomics; Mass spectrometry; Molecular imaging; Medicinal chemistry

Website: https://www.sbms.hku.hk/staff/yik-sham-clive-chung

 

Professor Q Hao

Research interest: Structural biology; Synchrotron radiation methods; Epigenetic regulators

Website: https://www.sbms.hku.hk/staff/hao-quan

 

Dr R Hervas Millan

Research interest: Functional protein aggregation; Functional amyloids; Electron-cryo microscopy; Memory persistence; Cellular memory

Website: https://www.sbms.hku.hk/staff/ruben-hervas-millan

 

Professor JD Huang

Research interest: Synthetic biology; Vaccines for infectious diseases and cancers; Biological pattern formation

Website: https://www.sbms.hku.hk/staff/jiandong-huang

 

Dr R Jauch

Research interest: Protein design and stem cell engineering; Directed molecular evolution in mammalian cells

Website: https://www.sbms.hku.hk/staff/ralf-jauch

 

Dr SC Kwon

Research interest: RNA biology and genome engineering

Website: http://www.sbms.hku.hk/staff/sung-chul-kwon

 

Professor PT Liu

Research interest: Stem cells; Genetics and genomics; Developmental Biology; Hematopoiesis and immune cell functions; Cancer cell killers; Cell-based therapies

Website: https://www.sbms.hku.hk/staff/pengtao-liu

 

Dr CM Qian

Research interest: Epigenetic​s and genome instability; Structural biology

Website: https://www.sbms.hku.hk/staff/qian-chengmin

 

Professor R Sun

Research interest: Advance virology and immunology by integrating genomic, proteomic, structural, quantitative, and deep learning approaches

Website: https://www.sbms.hku.hk/staff/sun-ren

 

Professor JA Tanner

Research interest: Nucleic acid nanotechnology and chemical biology

Website: https://www.sbms.hku.hk/staff/julian-alexander-tanner

 

Dr JSC Ti

Research interest: Integrating biochemistry, chemical biology and single-molecule microscopy to dissect the function and organisation of microtubules

Website: https://www.sbms.hku.hk/staff/shih-chieh-jeff-ti

 

Dr ASL Wong

Research interest: Genome editing; Protein engineering; Synthetic biology; Combinatorial genetics; Drug target discovery; Disease biology

Website: https://www.sbms.hku.hk/staff/alan-siu-lun-wong

 

Dr JWH Wong

Research interest: Cancer genomics; Proteomics and bioinformatics

Website: https://www.sbms.hku.hk/staff/jason-wing-hon-wong

 

Dr CH Yu

Research interest: Cell adhesion and cytoskeleton regulation; Podosome and invadopodium; Mechanobiology; Phosphatidylinositol signalling; Fluorescence microscopy

Website: https://www.sbms.hku.hk/staff/cheng-han-yu

SBSB2